Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
Very interesting study that shows Vitamin E succinate to decrease hepatocellular carcinoma by 77% ! It was actually caused/increased by vitamin E acetate .
I included the whole results section from the abstract ,because every point actually deserves it's own discussion .
Also vitamin A and D deficiency caused tumor increases . The tumors numbers increased by 6 fold ! Still let's me doubt the whole "Poison A+D " thing even more.
Next it confirms the detrimental effects that PUFA has! Simply replacing the soy in the diet with casein protein or dextrin sugar, reduced the carcinomas to almost nothing!
This is probably the mechanism of action of Vitamin E succinate as it protects from PUFA . Interesting that Vitamin E acetate doesnt do that .
It might also have to with the succinate they consumed which inhibits FFAs and is thus anti cancer .
@haidut actually posted a study showing that vitamin E acetate was able to prevent calcification, but he said that acetate form is of lower quality. Plus theres no reason the succinate form can't treat the calcification and as we saw in this study it is actually anti cancer as opposed to acetate. So if somebody tried to replicate the results of that study I would always go with vitmain E succinate instead of acetate.
"Elevated dietary tocopheryl acetate (E-Ac) caused a marked increase in liver size and in AfB1-induced HCCs in rainbow trout. 2.) Poor diets increased the HCC incidence. 3.) Elevated dietary tocopheryl succinate (E-Su) nearly eliminated HCC development in fish fed complete diets. Tocopheryl succinate in poor diets reduced HCCs by 77% compared to tocopheryl acetate diets. 4.) Trans-retinoic acid also reduced HCC incidence. 5.) Vitamins A and D deficiency caused tumor increases but had no effect on liver size. 6.) The use of casein and dextrin in the place of soybean textured vegetable protein, in poor diets nearly eliminated the HCC risk. 7.) Trout sera showed all three vitamin forms; free α-tocopherol (E-OH), tocopheryl acetate (E-Ac) and tocopheryl succinate (E-Su), from diets containing any of these vitamin analogues, suggesting both de-esterification and trans-esterification. 8.) E-Su is discussed in the light of an anti-cancer agent that is non toxic to normal tissue but that cohorts to it are needed."
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HCC numbers increased by 10 fold in 10 months. As early as 6 weeks on the diets the livers were becoming pale and enlarged. At 6 months on the highest E-Ac diets (16.25 gm/Kg diet) livers were twice as large as the controls. Liver enlargement and jaundice occurred whether aflatoxin was in the diet or not."
Hepatocellular carcinomas are promoted by tocopheryl acetate but eliminated by tocopheryl succinate - ScienceDirect
I included the whole results section from the abstract ,because every point actually deserves it's own discussion .
Also vitamin A and D deficiency caused tumor increases . The tumors numbers increased by 6 fold ! Still let's me doubt the whole "Poison A+D " thing even more.
Next it confirms the detrimental effects that PUFA has! Simply replacing the soy in the diet with casein protein or dextrin sugar, reduced the carcinomas to almost nothing!
This is probably the mechanism of action of Vitamin E succinate as it protects from PUFA . Interesting that Vitamin E acetate doesnt do that .
It might also have to with the succinate they consumed which inhibits FFAs and is thus anti cancer .
@haidut actually posted a study showing that vitamin E acetate was able to prevent calcification, but he said that acetate form is of lower quality. Plus theres no reason the succinate form can't treat the calcification and as we saw in this study it is actually anti cancer as opposed to acetate. So if somebody tried to replicate the results of that study I would always go with vitmain E succinate instead of acetate.
"Elevated dietary tocopheryl acetate (E-Ac) caused a marked increase in liver size and in AfB1-induced HCCs in rainbow trout. 2.) Poor diets increased the HCC incidence. 3.) Elevated dietary tocopheryl succinate (E-Su) nearly eliminated HCC development in fish fed complete diets. Tocopheryl succinate in poor diets reduced HCCs by 77% compared to tocopheryl acetate diets. 4.) Trans-retinoic acid also reduced HCC incidence. 5.) Vitamins A and D deficiency caused tumor increases but had no effect on liver size. 6.) The use of casein and dextrin in the place of soybean textured vegetable protein, in poor diets nearly eliminated the HCC risk. 7.) Trout sera showed all three vitamin forms; free α-tocopherol (E-OH), tocopheryl acetate (E-Ac) and tocopheryl succinate (E-Su), from diets containing any of these vitamin analogues, suggesting both de-esterification and trans-esterification. 8.) E-Su is discussed in the light of an anti-cancer agent that is non toxic to normal tissue but that cohorts to it are needed."
"
HCC numbers increased by 10 fold in 10 months. As early as 6 weeks on the diets the livers were becoming pale and enlarged. At 6 months on the highest E-Ac diets (16.25 gm/Kg diet) livers were twice as large as the controls. Liver enlargement and jaundice occurred whether aflatoxin was in the diet or not."
Hepatocellular carcinomas are promoted by tocopheryl acetate but eliminated by tocopheryl succinate - ScienceDirect
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