TNF Alpha

[paymanz]

I probably will edit this post and update it.

Magnesium and tnf alpha interaction
Elevated concentrations of TNF-alpha are related to low serum magnesium levels in obese subjects. - PubMed - NCBI

Adequate zinc intake is necessary for protection against tnf alpha and pufa
Zinc nutrition and apoptosis of vascular endothelial cells: implications in atherosclerosis. - PubMed - NCBI

Our data suggest that zinc deficiency exacerbates the detrimental effects of specific fatty acids (e.g., linoleic acid) and inflammatory cytokines, such as TNF, on vascular endothelial functions.

Tnf alpha ctivates mmp which is essential for repairing wounds and regeneration , but in excess or if happens when not necessary it becomes detrimental ,like in aids disease, which causes wasting and atrophy,
TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP. - PubMed - NCBI

Lidocaine and ropivacaine attenuated tnf alpha induced raise of mmp
Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the... - PubMed - NCBI
Aspirin does the same
Aspirin suppresses TNF-α-induced MMP-9 expression via NF-κB and MAPK signaling pathways in RAW264.7 cells
____________________________


Essential fatty acid deficiency(EFAD) and fasting lower tnf alpha, efad is more effective>> Inhibition of warm ischemic injury to rat liver, pancreas, and heart grafts by controlling the nutritional status of both donor and recipient. - PubMed - NCBI
Lioleic acid potentiates inflammatory action of tnf alpha
Effect of linoleic acid on endothelial cell inflammatory mediators. - PubMed - NCBI

These data suggest that selected fatty acids such as 18:2 can exert proinflammatory effects and, in addition, may markedly alter TNF-mediated inflammatory events

___________________

Tnf alpha related to obesity
Increased level of tumour necrosis factor‐alpha (TNF‐α) on the skin of Japanese obese males: measured by quantitative skin blotting
Tnf alpha increases cortisol
Tumor Necrosis Factor α and Interleukin 1β Enhance the Cortisone/Cortisol Shuttle | JEM
Vitamin d lowers tnf alpha and increases it in some types of cancer cell
Effects of vitamin D3 on expression of tumor necrosis factor-alpha and chemokines by monocytes. - PubMed - NCBI

Effect of vitamin D3 supplementation on TNF-α serum level and disease activity index in Iranian IBD patients

Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells. - PubMed - NCBI

Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women | Journal of Inflammation | Full Text

Vitamin E lowered HIIT indused high tnf alpha
Effect of vitamin E succinate on inflammatory cytokines induced by high-intensity interval training

Acute homocysteine administrationincreases tnf alpha in hippocampus and vitamin c prevented it
:: Journal of Epilepsy Research

Doxycycline and minocycline lower tnf alpha
Low Dose Doxycycline Decreases Systemic Inflammation And Improves Glycemic Control, Lipid Profiles,

Low dose Naltrexone lower tnf alpha
Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia. - PubMed - NCBI

Methylene blue supressed tnf alpha after carbon monoxide treatment
After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning. - PubMed - NCBI

Ketotifen lowers tnf alpha
Ketotifen in HIV-infected patients: effects on body weight and release of TNF-alpha. - PubMed - NCBI

In this study plasma TNF-α and soluble TNF recep￾tor concentrations were increased in HIV-infected sub￾jects compared to controls. Ketotifen administration
did not decrease these parameters but did decrease
TNF-α release from stimulated PBMCs.

Apparently H1 histamin antagonizing suppresses tnf alpha but H2 and H3 antihistamines increase it.
Cypro,ketotifen,diphenhydramine are H1 antihistamines.
Taurine lowers tnf alpha
[Effects of taurine on TNF-alpha and NF-kappaB expression of liver injury after limbs ischemia/reperfusion in rats]. - PubMed - NCBI

low dose boron decreases tnf alpha
Effect of Boron on Thymic Cytokine Expression, Hormone Secretion, Antioxidant Functions, Cell Proliferation, and Apoptosis Potential via the Extrac... - PubMed - NCBI

Lidocaine lowers tnf alpha
Lidocaine Effect On Tnf Alpha And NO After Endotoxin Exposure

Coconut oil lowers tnf alpha
Effects of coconut oil on glycemia, inflammation, and urogenital microbial parameters in female Ossabaw mini-pigs

Dietary phospholipids and whole egg consumption lowers tnf alpha or prevents its inflammatory signaling

Bioactive Egg Components and Inflammation

TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells. - PubMed - NCBI

And here is an interaction of tnf alpha and phospholipid, it prevents biosynthesis of phosphatidylcholine and its mediated partially by prostaglandins,which prevented by pentoxifylline to some degree
Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins. - PubMed - NCBI

Co2 may lower tnf alpha
Effect of CO2 on LPS-induced cytokine responses in rat alveolar macrophages. - PubMed - NCBI

CO2 abdominal insufflation decreases local and systemic inflammatory response in experimental acute pancreatitis. - PubMed - NCBI

Tribulus terrestris lowers tnf alpha
Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats. - PubMed - NCBI

Caffeine lowers tnf apha
Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway. - PubMed - NCBI

Theanine lowers the tnf alpha
Theanine is a candidate amino acid for pharmacological stabilization of mast cells. - PubMed - NCBI

Thophylline lowers tnf alpha
Effect of theophylline on the production of interleukin-1 beta, tumor necrosis factor-alpha, and interleukin-8 by human peripheral blood mononuclea... - PubMed - NCBI
Pentoxifylline lowers tnf alpha
https://www.hindawi.com/journals/pd/2015/108179/

 

[ecstatichamster]

Fantastic. Thank you.

 

[Owen B]

Great post. I've been trying to get to the bottom of a gnarly inflammation in my skin for a long time. There's these hard growths just under the skin with blood underneath.

I have looked at every official condition and every picture out there. From scleroderma to angioedema etc, etc. The specialists were no help. Dermatologists just wanted to throw megadoses of antibiotics at it because it was supposed to be an infection. I knew it was inflammatory and I had tracked down a study in a dermatology journal about low-dose doxy (under 50 mgs a day). I think I posted it and I think you may have even replied.

But when I started looking at histamines and mast cell problems that's when I got onto the TNF-alpha. But the link in this post about TNF stimulating activation of MMPs in the skin really hit the mark. That's when the light went on. Over expression of the vegatative system; the collagenase and the dermal fibroblasts.

I don't think it really matters what the h it's really called but now I know I'm in the ballpark with it. Cypro and ketotifen sound good. All the other links are real interesting.

What's the deal with prescription TNF inhibitors? Any good? Brutal?

Here's a study I just found on the anti-endotoxic effect of cypro thru TNF inhibition.

Anti-endotoxic shock effects of cyproheptadine in rats. - PubMed - NCBI

 

[paymanz]

Great post. I've been trying to get to the bottom of a gnarly inflammation in my skin for a long time. There's these hard growths just under the skin with blood underneath.

I have looked at every official condition and every picture out there. From scleroderma to angioedema etc, etc. The specialists were no help. Dermatologists just wanted to throw megadoses of antibiotics at it because it was supposed to be an infection. I knew it was inflammatory and I had tracked down a study in a dermatology journal about low-dose doxy (under 50 mgs a day). I think I posted it and I think you may have even replied.

But when I started looking at histamines and mast cell problems that's when I got onto the TNF-alpha. But the link in this post about TNF stimulating activation of MMPs in the skin really hit the mark. That's when the light went on. Over expression of the vegatative system; the collagenase and the dermal fibroblasts.

I don't think it really matters what the h it's really called but now I know I'm in the ballpark with it. Cypro and ketotifen sound good. All the other links are real interesting.

What's the deal with prescription TNF inhibitors? Any good? Brutal?

Here's a study I just found on the anti-endotoxic effect of cypro thru TNF inhibition.

Anti-endotoxic shock effects of cyproheptadine in rats. - PubMed - NCBI

i think i forgot to mention endotoxin here ,that lowering endotoxin and of course other toxins from intestines is probably the most important thing.the most basic one.

 

[olive]

If travis’ theory about hair loss is correct, then all of these substances would help fight hair loss? I know he has talked about the hair growth inducing effects of cyclosporine, which is a powerful TNF inhibitor.

Great thread btw, thanks for putting this all together.

 

[accelerator]

Great post. I've been trying to get to the bottom of a gnarly inflammation in my skin for a long time. There's these hard growths just under the skin with blood underneath.

I have looked at every official condition and every picture out there. From scleroderma to angioedema etc, etc. The specialists were no help. Dermatologists just wanted to throw megadoses of antibiotics at it because it was supposed to be an infection. I knew it was inflammatory and I had tracked down a study in a dermatology journal about low-dose doxy (under 50 mgs a day). I think I posted it and I think you may have even replied.

But when I started looking at histamines and mast cell problems that's when I got onto the TNF-alpha. But the link in this post about TNF stimulating activation of MMPs in the skin really hit the mark. That's when the light went on. Over expression of the vegatative system; the collagenase and the dermal fibroblasts.

I don't think it really matters what the h it's really called but now I know I'm in the ballpark with it. Cypro and ketotifen sound good. All the other links are real interesting.

What's the deal with prescription TNF inhibitors? Any good? Brutal?

Here's a study I just found on the anti-endotoxic effect of cypro thru TNF inhibition.

Anti-endotoxic shock effects of cyproheptadine in rats. - PubMed - NCBI

Curious about this; did you learn anything new about it since then?

 

[Owen B]

No i haven't. I dread having this looked at by the MDs. A dermatologist told me it was a bacterial infection and wanted to put me on megadoses of tetracycline.

A bacterial infection Ive had for 10 years? I'd be in sepsis and dead by now. Can even low-grade, functional sepsis and endotoxemia cause fibrosis? I don't think so but i could be wrong. But a bacterial infection that he's not even going to test for? It's like throwing something against the wall to see what sticks.

I'll have to go to a primary care MD and have her run an inflammatory profile and see what comes up. Maybe she could test endotoxin.

For now I'm just taking cyproheptadine and trying to keep my gut as clean as possible.

 

[Owen B]

I probably will edit this post and update it.

Magnesium and tnf alpha interaction
Elevated concentrations of TNF-alpha are related to low serum magnesium levels in obese subjects. - PubMed - NCBI

Adequate zinc intake is necessary for protection against tnf alpha and pufa
Zinc nutrition and apoptosis of vascular endothelial cells: implications in atherosclerosis. - PubMed - NCBI



Tnf alpha ctivates mmp which is essential for repairing wounds and regeneration , but in excess or if happens when not necessary it becomes detrimental ,like in aids disease, which causes wasting and atrophy,
TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP. - PubMed - NCBI

Lidocaine and ropivacaine attenuated tnf alpha induced raise of mmp
Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the... - PubMed - NCBI
Aspirin does the same
Aspirin suppresses TNF-α-induced MMP-9 expression via NF-κB and MAPK signaling pathways in RAW264.7 cells
____________________________


Essential fatty acid deficiency(EFAD) and fasting lower tnf alpha, efad is more effective>> Inhibition of warm ischemic injury to rat liver, pancreas, and heart grafts by controlling the nutritional status of both donor and recipient. - PubMed - NCBI
Lioleic acid potentiates inflammatory action of tnf alpha
Effect of linoleic acid on endothelial cell inflammatory mediators. - PubMed - NCBI

___________________

Tnf alpha related to obesity
Increased level of tumour necrosis factor‐alpha (TNF‐α) on the skin of Japanese obese males: measured by quantitative skin blotting
Tnf alpha increases cortisol
Tumor Necrosis Factor α and Interleukin 1β Enhance the Cortisone/Cortisol Shuttle | JEM
Vitamin d lowers tnf alpha and increases it in some types of cancer cell
Effects of vitamin D3 on expression of tumor necrosis factor-alpha and chemokines by monocytes. - PubMed - NCBI

Effect of vitamin D3 supplementation on TNF-α serum level and disease activity index in Iranian IBD patients

Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells. - PubMed - NCBI

Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women | Journal of Inflammation | Full Text

Vitamin E lowered HIIT indused high tnf alpha
Effect of vitamin E succinate on inflammatory cytokines induced by high-intensity interval training

Acute homocysteine administrationincreases tnf alpha in hippocampus and vitamin c prevented it
:: Journal of Epilepsy Research

Doxycycline and minocycline lower tnf alpha
Low Dose Doxycycline Decreases Systemic Inflammation And Improves Glycemic Control, Lipid Profiles,

Low dose Naltrexone lower tnf alpha
Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia. - PubMed - NCBI

Methylene blue supressed tnf alpha after carbon monoxide treatment
After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning. - PubMed - NCBI

Ketotifen lowers tnf alpha
Ketotifen in HIV-infected patients: effects on body weight and release of TNF-alpha. - PubMed - NCBI

Apparently H1 histamin antagonizing suppresses tnf alpha but H2 and H3 antihistamines increase it.
Cypro,ketotifen,diphenhydramine are H1 antihistamines.
Taurine lowers tnf alpha
[Effects of taurine on TNF-alpha and NF-kappaB expression of liver injury after limbs ischemia/reperfusion in rats]. - PubMed - NCBI

low dose boron decreases tnf alpha
Effect of Boron on Thymic Cytokine Expression, Hormone Secretion, Antioxidant Functions, Cell Proliferation, and Apoptosis Potential via the Extrac... - PubMed - NCBI

Lidocaine lowers tnf alpha
Lidocaine Effect On Tnf Alpha And NO After Endotoxin Exposure

Coconut oil lowers tnf alpha
Effects of coconut oil on glycemia, inflammation, and urogenital microbial parameters in female Ossabaw mini-pigs

Dietary phospholipids and whole egg consumption lowers tnf alpha or prevents its inflammatory signaling

Bioactive Egg Components and Inflammation

TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells. - PubMed - NCBI

And here is an interaction of tnf alpha and phospholipid, it prevents biosynthesis of phosphatidylcholine and its mediated partially by prostaglandins,which prevented by pentoxifylline to some degree
Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins. - PubMed - NCBI

Co2 may lower tnf alpha
Effect of CO2 on LPS-induced cytokine responses in rat alveolar macrophages. - PubMed - NCBI

CO2 abdominal insufflation decreases local and systemic inflammatory response in experimental acute pancreatitis. - PubMed - NCBI

Tribulus terrestris lowers tnf alpha
Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats. - PubMed - NCBI

Caffeine lowers tnf apha
Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway. - PubMed - NCBI

Theanine lowers the tnf alpha
Theanine is a candidate amino acid for pharmacological stabilization of mast cells. - PubMed - NCBI

Thophylline lowers tnf alpha
Effect of theophylline on the production of interleukin-1 beta, tumor necrosis factor-alpha, and interleukin-8 by human peripheral blood mononuclea... - PubMed - NCBI
Pentoxifylline lowers tnf alpha
https://www.hindawi.com/journals/pd/2015/108179/

If you're still interested in editing this, I got interested in phages and found this Effective phage therapy is associated with normalization of cytokine production by blood cell cultures. - PubMed - NCBI

 

[Riley Escobar]

How do these compare to TNF blockers like Humira and Remicade ..especially for folks with autoimmune diseases like Ulcerative Colitis, Crohn's, RA etc..

 

[moa]

@paymanz old post but interesting.

wonder how much tnf alpha is important for weight loss and what is lowering it the most in this context.

magnesium and zinc come first in there, there's evidence a high magnesium/zinc ratio will cause calcium uptake by cells (similar to high PTH???).

Magnesium and Zinc Intake Ratio Mediates the Increase of Coronary Artery Calcification through Upregulating Interleukin 6

Magnesium and Zinc Intake Ratio Mediates the Increase of Coronary Artery Calcification through Upregulating Interleukin 6

The relation between dietary minerals and coronary artery calcification (CAC) has been emphasized. However, the effects of multiple dietary minerals on CAC progression remain unclear. This study Investiagetes the effect of combined dietary mineral intake ...

www.ncbi.nlm.nih.gov

they both increase metabolic rate :

The effects of combined magnesium and zinc supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease - Lipids in Health and Disease

Background The present research aimed to analyze the impacts of magnesium and zinc supplements on glycemic control, serum lipids, and biomarkers of oxidative stress and inflammation in patients suffering from coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). Methods According to...

lipidworld.biomedcentral.com

 

[Highserotonin90]

@moa Do you know anything else that may be effective against TNF alpha?

 

[moa]

@Highserotonin90 no, don't know much about it, i was searching for things to decrease weight in a healthy way.