estrogen stimulated breast cancer (desirable effect from alpha, delta, gamma, or gamma mixed tocopherols)
www.ncbi.nlm.nih.gov
0.2% of diet (>1g tocopherol human?) alpha slowed estrogen cancer, gamma and delta performed better.
but mixed tocopherols high in gamma performed the best (y-TmT).
estrogen stimulated breast cancer #2 (big undesirable effect from DL-a-tocopherol acetate)
with lung tumors
(big desirable effect from Alpha tocopherol succinate)
aacrjournals.org
Mechanism is the succinate form works by inhibiting ubiquinol at complex II in mitochondria.
Human cancers tend to still have complex II intact.
so with this the mitochondria builds up ROS which causes apoptosis / cell death. its different to usual vitamin E
So I wondered if this would cause toxic effects on healthy cells too,
apparently not (or not as much) as the healthy cells can tolerate the extra stress better than tumor cells. so the effect is basically selective on cancer in terms of immediate effect
But interfering with complex II probably isn't great over the long term if just using this generally instead of with cancer. looks like a potent option there though
Skin absorption https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/15216549900201543
Through the skin dissolving the powder in oil , ~50% was absorbed & only 6% is converted to tocopherol without the succinate.
So if going by these studies for cancer then alpha tocopherol succinate is likely optimal, followed by mixed tocopherols high in gamma, & dl-alpha tocopherol acetate form could have opposite effects. not sure about dl-alpha
[interestingly on the ray peat emails wiki ray preferred high gamma mixed vs high alpha]
[for general day to day intakes outside of cancer only a low mg amount of vit e is needed for countering pufa. https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S000711451500272X rounding up its 1mg vit e per gram linoleic acid , so even people with high pufa intake don't need the megadoses in supplements
if you look around at foods its rare to find a food with > a couple milligrams. we wouldn't have got anywhere near 100s of milligrams generally. Vit E has a long half life and the body stores it,
But say we want to 2x historic intake when taking into account modern environment higher in toxins, usual supplements are overdosed multiple times higher than that still. these are more for use like a drug treating something, if right form is used. otherwise "smaller" intakes e.g 20mg are significant doses]
raypeatforum.com
side note i wonder if the mole removal effects ray mentioned for DHEA was actually because of the vit E content (think he used dhea in vit e?). someone here posted a thread showing oral vit E caused their skin tag to drop off in like 10 days & repeated the result.
on a quick look apparently skin tags have more estrogen / androgen receptors A STUDY OF ANDROGEN AND ESTROGEN RECEPTORS α, β IN SKIN TAGS
and study #1 showed alpha tocopherol had mild anti estrogen effects compared to delta / gamma.
wonder if topical mixed high in gamma works well on moles / skin tags?
Inhibitory effects of γ- and δ-tocopherols on estrogen-stimulated breast cancer in vitro and in vivo
Estrogens have been implicated as complete carcinogens for breast and other tissues through mechanisms involving increased cell proliferation, oxidative stress and DNA damage. Because of their potent antioxidant activity and other effects, tocopherols ...
www.ncbi.nlm.nih.gov
0.2% of diet (>1g tocopherol human?) alpha slowed estrogen cancer, gamma and delta performed better.
but mixed tocopherols high in gamma performed the best (y-TmT).
estrogen stimulated breast cancer #2 (big undesirable effect from DL-a-tocopherol acetate)
with lung tumors
(big desirable effect from Alpha tocopherol succinate)
Suppression of Tumor Growth In vivo by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex II
Abstract. Purpose: Vitamin E analogues are potent novel anticancer drugs. The purpose of this study was to elucidate the cellular target by which these agents, represented by α-tocopoheryl succinate (α-TOS), suppress tumors in vivo, with the focus on the mitochondrial complex II...
aacrjournals.org
Mechanism is the succinate form works by inhibiting ubiquinol at complex II in mitochondria.
Human cancers tend to still have complex II intact.
so with this the mitochondria builds up ROS which causes apoptosis / cell death. its different to usual vitamin E
So I wondered if this would cause toxic effects on healthy cells too,
apparently not (or not as much) as the healthy cells can tolerate the extra stress better than tumor cells. so the effect is basically selective on cancer in terms of immediate effect
But interfering with complex II probably isn't great over the long term if just using this generally instead of with cancer. looks like a potent option there though
Skin absorption https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/15216549900201543
Through the skin dissolving the powder in oil , ~50% was absorbed & only 6% is converted to tocopherol without the succinate.
So if going by these studies for cancer then alpha tocopherol succinate is likely optimal, followed by mixed tocopherols high in gamma, & dl-alpha tocopherol acetate form could have opposite effects. not sure about dl-alpha
[interestingly on the ray peat emails wiki ray preferred high gamma mixed vs high alpha]
[for general day to day intakes outside of cancer only a low mg amount of vit e is needed for countering pufa. https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S000711451500272X rounding up its 1mg vit e per gram linoleic acid , so even people with high pufa intake don't need the megadoses in supplements
if you look around at foods its rare to find a food with > a couple milligrams. we wouldn't have got anywhere near 100s of milligrams generally. Vit E has a long half life and the body stores it,
But say we want to 2x historic intake when taking into account modern environment higher in toxins, usual supplements are overdosed multiple times higher than that still. these are more for use like a drug treating something, if right form is used. otherwise "smaller" intakes e.g 20mg are significant doses]
Vitamin E succinate decreases melanoma size by 650% in vivo
I have already posted a study about vitamin E succinate (VES) beeing able to decrease liver carcinoma by 77% (Vitamin E Succinate Very Effective Against Liver Carcinoma ,acetate Form Increases It) There have previously been studies on VES and melanoma in vitro and they all showed decreases in...
side note i wonder if the mole removal effects ray mentioned for DHEA was actually because of the vit E content (think he used dhea in vit e?). someone here posted a thread showing oral vit E caused their skin tag to drop off in like 10 days & repeated the result.
on a quick look apparently skin tags have more estrogen / androgen receptors A STUDY OF ANDROGEN AND ESTROGEN RECEPTORS α, β IN SKIN TAGS
and study #1 showed alpha tocopherol had mild anti estrogen effects compared to delta / gamma.
wonder if topical mixed high in gamma works well on moles / skin tags?
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