SSRI Use In Children Dramatically Increases Risk Of Diabetes In Adulthood

[haidut]

The bad news for SSRI just keep on piling. Given serotonin's role as a master metabolic inhibitor this findings is not really surprising. There are a number of clinical trials underway with serotonin synthesis (TPH) inhibitors as treatment of obesity, insulin resistance and diabetes II. As of right now these trials are all in stage III indicating they are all successful thus far.
This may explain why no new SSRI drugs have been developed in the last decade and efforts are now focused on SNRI/SSRE and even dopamine agonists like pramipexole. FDA is even about to approve MDMA (ecstasy) for treatment of PTSD. The rumor is they will also soon approve ketamine for depression and may even consider micro-dosing LSD for intractable mental conditions. At the same time the ads for SSRI on TV have intensified, which is probably because Big Pharma is desperately trying to squeeze the last few drops of profit from these drugs before they go into oblivion. But don't expect any pharma exec to get sued or go to jail for the millions of people these drugs damaged or drove to suicide/homicide.

Antidepressants in Youth Associated With Increased Risk of Type 2 Diabetes | MedicalResearch.com

"...Antidepressants are one of the most commonly used psychotropic medication classes in U.S. youth, with serotonin reuptake inhibitors representing a large majority of total antidepressant use in youth. The most interesting finding was that the current use of serotonin reuptake inhibitors in youth was associated with an increased risk of type 2 diabetes mellitus, and this increased risk intensified further with the increasing duration of use and with the increasing dose. A secondary analysis also revealed that the risk of incident type 2 diabetes was most apparent in youth who used serotonin reuptake inhibitors for longer durations AND in greater daily doses."

 

[ecstatichamster]

how does adamantane fit in here...

 

[aguilaroja]

The bad news for SSRI just keep on piling. Given serotonin's role as a master metabolic inhibitor this findings is not really surprising.
Antidepressants in Youth Associated With Increased Risk of Type 2 Diabetes | MedicalResearch.com
"...Antidepressants are one of the most commonly used psychotropic medication classes in U.S. youth, with serotonin reuptake inhibitors representing a large majority of total antidepressant use in youth. ...

The list of recent "associations" includes persistent pulmonary hypertension of the newborn, and increased risk for intracranial hemorrhage.

SSRI and SNRI use during pregnancy and the risk of persistent pulmonary hypertension of the newborn. - PubMed - NCBI
“The use of selective serotonin reuptake inhibitors (SSRIs) in late pregnancy may be associated with an increased risk of persistent pulmonary hypertension of the newborn (PPHN).”
“Use of SSRIs in the second half of pregnancy was associated with the risk of PPHN.”

Association of Selective Serotonin Reuptake Inhibitors With the Risk for Spontaneous Intracranial Hemorrhage. - PubMed - NCBI
“Current SSRI use was associated with an increased risk for ICH (RR, 1.17; 95% CI, 1.02-1.35) relative to TCAs, highest during the first 30 days of use (RR, 1.44; 95% CI, 1.04-1.99), and translating in very few additional events.”

 

[Travis]

Even if someone were convinced that extra serotonin was a good thing, SSRIs are a bizarre way to go about raising it considering all of Fernstrom's research. Simply eating the precursor tryptophan will do this, although its use for this reason is denigrated by psychiatrists since it's something you can buy anywhere. Whey powder is a reliable way to increase serotonin in the brain.

There is a persistent myth that the enzyme tyrosine hydroxylase in the brain is saturated with substrate so that taking extra levodopa has no effect. This is not true, as L-dopa has been shown to lower prolactin synthesis—a classic effect of dopamine. Bromocriptine will lower prolactin, which is a powerful growth factor for cells that have a receptor for it.