Yes, the more end-point steroids you use the more risk you have of creating disbalances upwards the chain since there is usually a feedback mechanism of some sorts. So, if steroids have to be combined I would combine ideally DHEA + DHT + T, and if you only have two of them I would do DHT + DHEA or T + DHEA. The DHEA itself has very prometabolic effects and has some metabolites that are absolutely crucial for immunity. So, I think DHEA should be present in any combo. Pregnenolone + dhea + androsterone is probably the best legal way to optimize steroids as you get the strong androgen androsterone, the systemic health-promoter DHEA, and the progesteogenic and steroid synthesis boosting effects of pregnenolone. If DHT was legal, I would use that instead of androsterone, but if you look at the master thread on androsterone you will see that it converts back to DHT rather easily and is a true DHT prohormone without much of a chance of converting into something harmful.