Low Toxin Testimonials Please, can somebody explain - how does the body produce pregnenolone, if it isn't relying on vitamin A intake?

[YourUniverse]

Vitamin A + cholesterol + saturated fat (or vA + sugar) is my basic understanding of why vitamin A is needed. For the low vitamin A people, can someone explain how we make pregnenolone if not from A, or at least what is happening with this equation?

 

[Peater]

I've raised this point before. Why did Ray have to supplement preg/prog/DHEA as he was getting a huge amount of the "necessary cofactors".

 

[Nick]

Vitamin A + cholesterol + saturated fat (or vA + sugar) is my basic understanding of why vitamin A is needed. For the low vitamin A people, can someone explain how we make pregnenolone if not from A, or at least what is happening with this equation?

I'm not aware of anyone who thinks vitamin A is turned into anything, or any evidence that suggests it is. Even those who think it's necessary just think it is a modulator of hormone production. The counter argument is that any hormone production increase is to compensate for the toxic damage.

 

[Sebastian B]

Vitamin A does not directly affect steroidogenesis.

 

[JohnHafterson]

Good question do a Google search of "retinoids steroidogenesis" - read some of the papers may give you a better idea for or against

I'm not concerned with vitamin a - I get some in my diet not a ton but not deficiency levels either....

 

[DanDare]

Vitamin A + cholesterol + saturated fat (or vA + sugar) is my basic understanding of why vitamin A is needed. For the low vitamin A people, can someone explain how we make pregnenolone if not from A, or at least what is happening with this equation?

This is not a legitimate chemical equation. If you look at the process of making pregnenolone it doesn't look like this. It's a peat/ Danny Roddy simplification/ fabrication. Even in their 'equation' they say something like ' in the presence of vitamin A'

You'll find vitamin a's involvement is indirect. I.e :

Bing chat gtp:​

Vitamin A plays an indirect role in the synthesis of pregnenolone. It is essential for the proper functioning of the adrenal glands, where pregnenolone is produced. Specifically, vitamin A is involved in the regulation of gene expression and the maintenance of cellular health, which can influence the production of steroid hormones, including pregnenolone.

So the involvement of vitamin a is supposed to be done kind of catalyst for gene expression... Yet this is up for debate since people have now shown to still function well ( in fact better than ever) despite extreme avoidance diets.

 

[Sebastian B]

This is not a legitimate chemical equation. If you look at the process of making pregnenolone it doesn't look like this. It's a peat/ Danny Roddy simplification/ fabrication. Even in their 'equation' they say something like ' in the presence of vitamin A'

You'll find vitamin a's involvement is indirect. I.e :

Bing chat gtp:​

Vitamin A plays an indirect role in the synthesis of pregnenolone. It is essential for the proper functioning of the adrenal glands, where pregnenolone is produced. Specifically, vitamin A is involved in the regulation of gene expression and the maintenance of cellular health, which can influence the production of steroid hormones, including pregnenolone.

So the involvement of vitamin a is supposed to be done kind of catalyst for gene expression... Yet this is up for debate since people have now shown to still function well ( in fact better than ever) despite extreme avoidance diets.

Vitamin A primarily plays a role in cell differentiation.

 

[DanDare]

Vitamin A primarily plays a role in cell differentiation.

Allegedly it does but the people differentiating cells just fine after years of extreme avoidance diets suggest either the quantity required is vastly overestimated or infact it isn't essential at all.

 

[Peater]

Allegedly it does but the people differentiating cells just fine after years of extreme avoidance diets suggest either the quantity required is vastly overestimated or infact it isn't essential at all.

Agreed. Stem cell differentiation is at its most intense during early embryonic development - so why are pregnant women advised to avoid VA even by mainstream medicine?

Surely they would need loads of it, if it was crucial to the process.

 

[Sebastian B]

Vitamin A is both necessary and potentially dangerous if taken in excessive amounts, depending on the context. I don't see why there needs to be an all-or-nothing approach to vitamin A, especially considering the extensive research showing its involvement in various biological processes, as well as studies indicating that people who consume vitamin A from foods as part of a balanced diet have lower rates of cancer.

 

[Sebastian B]

The studies on vitamin A toxicity were conducted using supplements, whereas the studies showing benefits involved the consumption of vitamin A from whole foods as part of a balanced diet.

 

[Peater]

The studies on vitamin A toxicity were conducted using supplements, whereas the studies showing benefits involved the consumption of vitamin A from whole foods as part of a balanced diet.

I've never taken a vitamin A supplement but eaten plenty of liver, dairy etc and am noticing improvement from cutting it out.

 

[Sebastian B]

I've never taken a vitamin A supplement but eaten plenty of liver, dairy etc and am noticing improvement from cutting it out.

As you should. 1 oz of beef liver contains the vitamin A equivalent of about 40 eggs. It’s very high in vitamin A, and if you're not consuming soluble fiber, you can be sure it will accumulate in your system. That’s why I’ve often emphasized that eating vitamin A from whole foods as part of a balanced diet should generally be safe. However, if you've already developed vitamin A toxicity, it’s important to avoid high sources of preformed vitamin A, like liver and supplements.

 

[DanDare]

Vitamin A is both necessary and potentially dangerous if taken in excessive amounts, depending on the context. I don't see why there needs to be an all-or-nothing approach to vitamin A, especially considering the extensive research showing its involvement in various biological processes, as well as studies indicating that people who consume vitamin A from foods as part of a balanced diet have lower rates of cancer.

I understand you think it is necessary and I also understand the standard reasons according to the scientific literature. It's not necessary to repeat the mainstream position.

The context here is questioning the idea that vitamin a is essential for the synthesis of pregnenolone, and referencing the health of people avoiding vitamin a as experimental evidence that contradicts the mainstream model of vitamin a and cell differentiation. It is not advocating an all or nothing approach to it's incorporation in diet...

 

[Sebastian B]

I understand you think it is necessary and I also understand the standard reasons according to the scientific literature. It's not necessary to repeat the mainstream position.

The context here is questioning the idea that vitamin a is essential for the synthesis of pregnenolone, and referencing the health of people avoiding vitamin a as experimental evidence that contradicts the mainstream model of vitamin a and cell differentiation. It is not advocating an all or nothing approach to it's incorporation in diet...

Just because people have experienced positive results from removing vitamin A from their diet for a short period of time does not provide evidence that vitamin A is unnecessary or contradict established science. Even if symptoms improve after less than a year of eliminating vitamin A-rich foods, it could take several years, potentially up to 10, for the liver to fully deplete its stores of vitamin A, as the liver releases it gradually to maintain bodily functions.

 

[DanDare]

Just because people have experienced positive results from removing vitamin A from their diet for a short period of time does not provide evidence that vitamin A is unnecessary or contradict established science. Even if symptoms improve after less than a year of eliminating vitamin A-rich foods, it could take several years, potentially up to 10, for the liver to fully deplete its stores of vitamin A, as the liver releases it gradually to maintain bodily functions.

Clearly I disagree with you so I won't repeat myself beyond saying if someone gets better each year for ten years ( Grant Genereux) and has a lower vitamin a serum each year, close to zero, then it is indeed evidence that falsifies the mainstream model. You can continue to disagree until the cows come home. The model says its essential and stipulates deficiency at levels far above his serum levels, and states he should have a host of symptoms which he doesn't have. The end.