Magnoil - Liquid Magnesium

[Candeias]

Personally I feel this is a great product in general. But doing it a lot or large doses can interfere with calcium metabolism. I think calcium from milk leans my face and too much magnesium bloats my face and body. Unless you drink a lot of milk, I don't see why you would want to take large doses of this product because it's potent. Excess magnesium, especially with low dietary consumption of calcium or excess of phosphate, increases the conversion from vitamin D to the active form, calcitriol, which can increase serotonin in the brain. Serotonin tends to cause bone loss, increasing parathyroid hormone.

I feel an increase in serotonin the next day with just 5 drops, is it the increase in the "active" Calcitriol behind this reaction?

 

[bagotage]

In stock again soon I hope? @haidut

 

[Kray]

Neurotoxicity of pyroglutamic acid - Brain Health

Did Haidut or anyone else respond to this post re: pyroglutamic acid?

 

[SnickeD]

How much elemental magnesium per serving Georgi? Magnesium L-pidolate: 333mg. I suppose that is the ammount of the magnesium complex I am getting. Thank you.

 

[AinmAnseo]

So, if someone is using a dose or half dose of magnoil at night, should they avoid using a dose of mag bicarbonate (about 300 mg elemental mag) (something that haidut has talked about)?

 

[AinmAnseo]

I have been taking Magnoil 20 drops (forearm) and pyrucet 20 drops (stomach)
My sleep is better, I’m calmer, hungrier and warmer. Love it!

What does the pyrucet do for you?

 

[golder]

What does the pyrucet do for you?

Pyrucet surely not at the same time as the Magnoil before bed? That would keep me awake for hours!

 

[Alex Jaramillo]

What does the pyrucet do for you?

I could not discern at the time or now the benefit of pyrucet. All of those benefits were from the magnesium.

 

[Alex Jaramillo]

Pyrucet surely not at the same time as the Magnoil before bed? That would keep me awake for hours!

At the same time yes but taken in the morning.

 

[Kray]

Wouldn’t that be a bad thing?

Thought REM sleep was vital

REM IS dreamless sleep, a good thing

 

[Sapien]

REM IS dreamless sleep, a good thing

wrong,

well the fact that rem = dreamless is wrong, i dont know enough to comment on if REM is good or bad

 

[Kray]

wrong,

well the fact that rem = dreamless is wrong, i dont know enough to comment on if REM is good or bad

Sorry I misspoke. Thought I had been told on good authority by a practitioner, but hadn't checked it out myself. But after reading up, it is quite confusing as there are various stages of REM sleep, and depending on which one a person may/may not dream or may/may not remember. One thing this person did say that was confirmed by what I read, is that during the deep REM sleep, one goes into somewhat of a state of paralysis.

Here is the source I read from- Stages of Sleep: What Happens in a Sleep Cycle | Sleep Foundation

Reading from the article, REM is considered to be good and tends to decrease with age, and is affected by other factors.

Thanks for the correction

 

[Nik665]

I think that when taken orally, due to the DMSO it probably absorbs almost immediately through the oral mucosa, which is akin to sublingual administration. The latter favors the brain in terms of effects and distribution, so even low doses could cause such effects. The brain controls even bowel function through the cholinergic system and prolactin release, so if L-PGA opposes those in the brain it could have a powerful effect on bowel function.

Does this mean if taken orally prolactin may increase?

 

[Kray]

I have been using Magnoil everyday for 4 years now. Most recently I used 3-6 drops every evening on my abdomen or back. I have had insomnia for some time where I would sleep great for 4-5 hours, be awake for 2 and maybe get a little more sleep before having to get up. I wonder if the insomnia is caused by the L-PGA.

I didn't use it for two days and slept well for two nights. Then I had a lot of pain in my hips and thighs so on the second day I used some more Magnoil that relieved the pain but that night the insomnia returned. Today I used MgCl topically on my hips and thighs and so far so good. I will give the Magnoil a break to see if I can sleep better consistently.

Hi Dolomite- Any update? Back to Magnoil, or still using MgCl? If so, what brand gives best result for sleep, muscle benefits, and what dose just for reference?
Thank you.

 

[Sherbert]

Wondering if melanon and magnoil can be applied together. Does anyone know?

 

[G1986]

NOTE (12/16/2022): Due to occasional supply shortages of the L-pidolate salt of magnesium, some batches of Magnoil may contains magnesium sulfate instead. Adding the product to the shopping cart will show, which option is being currently offered/sold. The sulfate salt has a higher percentage elemental magnesium than the L-pidolate salt, so for some people that may actually be preferable. However, the writings below on the benefits of pyroglutamic acid would no longer apply when the sulfate salt is used. We will monitor sales and feedback from clients and eventually may settle down on using only one of those salts, or maybe offer Magnoil in two options - as a sulfate or L-pidolate salts.
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As many forum users know, magnesium (Mg) is one of the most important minerals for proper metabolic function. It is a required cofactor for hundreds of metabolic enzymes, including the crucial mitochondrial enzyme pyruvate dehydrogenase (PDH), ATP synthesis, and ATP transport in the bloodstream (as a Mg-ATP complex). In addition, Mg plays an important role in various signalling mechanisms within the nervous system including GABA, NMDA, HPA, calcium channels, and so on. Peat has written a lot on the topic of Mg and sodium and their deficiencies in hypothyroidism. One recent metareview study concluded that 80%+ of people in the Western world suffer from some level of Mg deficiency. With that in mind, a lot of people are supplementing with oral Mg in an effort to raise both serum and tissue levels. However, there are a number of problems with that approach. The first one is that almost all of the Mg salts commonly sold as supplements have poor absorption from the GI tract. For most salts, the reported absorption is usually less than 40%. Out of that absorbed portion, an even smaller proportion is retained since Mg retention depends on thyroid and ATP (as mentioned above). According to several studies, only about 10%-15% of the absorbed Mg is retained within tissues. Finally, virtually all of the Mg salts sold as supplements tend to irritate the GI tract and/or easily cause diarrhea, and this is something Peat has reported first-hand. The combination of all of these factors makes Mg replenishment a VERY challenging tasks unless somebody is admitted to the ER/hospital and receives an IV drip of Mg. Clearly the latter is not a practical or desirable option for most people.

Some vendors have realized the issue with oral Mg supplementation and have tried to come up with transdermal products, which in principle should avoid the issues of GI irritation and poor absorption/retention. In addition, raising magnesium levels has been shown to reverse the age-associated decline in DHEA levels, and likely has similar beneficial effects on pregnenolone levels as well. However, the only commercially viable product that I have seen so far uses a concentrated magnesium chloride (Mg-Cl) solution (in water). Not only is that solution irritating to the skin but several studies that looked at blood and tissue biomarkers of Mg stores claimed that very little (if anything) gets absorbed from that product. This is not surprising, considering that water is a very poor carrier of chemicals through the skin (which has been confirmed in countless human trials) unless it is combined with a penetration enhancer of some sort. Some other vendors have tried to improve the transdermal effectiveness of Mg-Cl by adding ethanol, polyethylene glycol, propylene glycol, etc. The issue with that approach is that most magnesium salts are very poorly soluble in alcohols/glycols, which results in very little Mg being present in the product and thus the overall Mg delivery into the system is possibly even lower than the plain Mg-Cl + water combination.

If somebody could resolve the issue of getting Mg through the skin it could provide a very desirable method for Mg supplementation that avoids most of the issues mentioned previously. We believe that our product described in this thread resolves many of these issues. After more than 10 months of testing with more than 30 different magnesium salts and pretty much every commercially available solvent, we finally found a combination that appears to work well. As a result, we are pleased to present our product Magnoil. It uses Magnesium L-pidolate as the Mg source and DMSO as a solvent. Magnesium L-pidolate is simply the salt of magnesium with L-pyroglutamic acid (L-PGA). I have posted about L-PGA before and it is one of the ingredients in our product Cardenosine. It just so happens that Magnesium L-pidolate is perhaps the only Mg salt that is soluble in good transdermal carriers like DMSO in amounts that makes transdermal supplementation practical. It has been used clinically for years and is available as an OTC magnesium supplement. The combination of Mg and L-PGA seems to have some unique neurotrophic effects, which are likely due to the effects of L-PGA on the brain. Some of those effects, including increasing dopamine synthesis and improving glucose metabolism, are discussed in studies posted in the Cardenosine thread.
Now, this brings us to the choice of solvent - DMSO. I know DMSO has acquired a bit of bad rep here but after running tests on several of our human volunteers (including yours truly) I suspect a lot of that bad rep can be reversed. It appears that not only does DMSO allow for full absorption of the dissolved Mg L-pidolate through the skin, but the combination of the two has some unique effects not seen in other products using DMSO as a solvent. First of all, for some reason there is no visible skin irritation/redness/itching when using the solution on the skin. At least not in the 3 volunteers that tried Magnoil on their skin for several days in a row. This is a notable difference compared to other DMSO solutions such as the older version of our steroid products, which caused skin irritation in some people. Second, there seems to be no skin drying or peeling, which DMSO is also known to cause sometimes. Finally, after application of the solution and allowing for about 20min to achieve complete absorption, the skin is left very smooth and feels quite rejuvenated. The solution is viscous and feels very much like a gel. It is sticky after initial application, which is something people noticed with Cardenosine. This is likely due to the L-PGA component, as it is known to acquire a sticky texture when in solution. However, that mild stickiness and gel-like consistency makes the solution very suitable for skin application because stays on the skin almost like a cream, and it does not run down or drip on the ground as it often happens with more liquid solutions. In addition, another cool property of the product is that L-PGA is itself a transdermal penetration enhancer, as I also mentioned in the Cardenosine thread. As such, it likely synergizes with the transdermal effectiveness of DMSO to improve absorption even more.

Our informal tests show that within a few minutes after application the typical effects of increased magnesium levels are observed - i.e. increased temps, pink color of previously pale/blue skin, calmness, anxiolytic effect, and even sedation when higher dose are used. One of the people who tried it has chronic constipation due to IBS-C and reported increased bowel movements - from 1 every 2 days to 2 per day. So, it does look like Magnoil is capable of delivering magnesium systemically and to tissues, but the ultimate test would be more people using it and reporting their results. We are really excited about it, because we don't know of any other product on the market (or in development) that has these features.

The name Magnoil is an acronym composed of portion of the words magnesium and oil. Of course, it does not contain any oils but the name is a reference to the gel-like and oily consistence of the solution due to the high amount of magnesium dissolved in it. The product can be ordered from the page below.
www.idealabsdc.com

Note: This product contains raw material(s) meant for external use only, in cosmetic or other formulations designed for such external use.

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Magnoil is a liquid magnesium supplement suitable for skin application. Magnesium has a unique and highly important role in human health. The mineral is a required cofactor for over 300 enzymes in the organism, including the crucial enzyme PDH. In addition, it has a well-recognized role in the CNS and various other systems including GABA/glycine receptors, NMDA, calcium channels, inflammation (CRP, NF-kB, TNFa, etc).

Serving size: 25 drops
Servings per container: about 30
Each serving contains the following ingredients:

Magnesium L-pidolate: 333mg

OR (see NOTE at the top of thread for more info)

Magnesium sulfate: 200mg

Other ingredients: add product to shopping cart to see info
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References:

CNS/mood/cognition
[Molecular mechanisms of pidolate magnesium action and its neurotropic affects]. - PubMed - NCBI
"...RESULTS: Neurotropic effects of magnesium pyroglutamate are due to an influence on the synthesis of neuropeptides containing pyroglutamate (orexin, thyroliberin, neurotensin etc) and due to the similarity between pyroglutamate-anion with some neuroactive components (L-theanine, 2-pirrolydinone, piracetam). CONCLUSION: The results of the study suggest neuroprotective, sedative and antidepressive properties of magnesium pyroglutamate which are realized by pyroglutamate-anion in the synergism with magnesium cation."

Magnesium as a preventive treatment for paediatric episodic tension-type headache: results at 1-year follow-up. - PubMed - NCBI
Magnesium as a treatment for paediatric tension-type headache: a clinical replication series. - PubMed - NCBI
Visual evoked potentials and serum magnesium levels in juvenile migraine patients. - PubMed - NCBI
Reversible model of magnesium depletion induced by systemic kainic acid injection in magnesium-deficient rats: I--Comparative study of various magn... - PubMed - NCBI
Inhibition of mouse-killing behaviour in magnesium-deficient rats: effect of pharmacological doses of magnesium pidolate, magnesium aspartate, magn... - PubMed - NCBI
[Psychopharmacological properties of three magnesium salts: pidolate, lactate and aspartate]. - PubMed - NCBI
[Magnesium in the prophylaxis of primary headache and other periodic disorders in children]. - PubMed - NCBI


CVD/circulation/blood pressure/anemia
[Effects of magnesium pidolate on cardiovascular hemodynamics]. - PubMed - NCBI
[Effects of magnesium pidolate on cardiovascular hemodynamics]. - PubMed - NCBI
Magnesium for treating sickle cell disease. - PubMed - NCBI
Late outcome of a randomized study on oral magnesium for premature complexes. - PubMed - NCBI
Late Outcome of a Randomized Study on Oral Magnesium for Premature Complexes. - PubMed - NCBI
Successful improvement of frequency and symptoms of premature complexes after oral magnesium administration. - PubMed - NCBI
Oral magnesium supplementation reduces ambulatory blood pressure in patients with mild hypertension. - PubMed - NCBI
Promising therapies in sickle cell disease. - PubMed - NCBI
Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia. - PubMed - NCBI
[Clinical trials of new therapeutic pharmacology for sickle cell disease]. - PubMed - NCBI
Oral magnesium pidolate: effects of long-term administration in patients with sickle cell disease. - PubMed - NCBI
The effect of dietary magnesium supplementation on the cellular abnormalities of erythrocytes in patients with beta thalassemia intermedia. - PubMed - NCBI
Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease. - PubMed - NCBI


Metabolism/diabetes
Effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus. - PubMed - NCBI
Effects of magnesium supplements on blood pressure, endothelial function and metabolic parameters in healthy young men with a family history of met... - PubMed - NCBI
Oral magnesium supplementation improves vascular function in elderly diabetic patients. - PubMed - NCBI
Beneficial effects of oral magnesium supplementation on insulin sensitivity and serum lipid profile. - PubMed - NCBI
[Comparative study of the short-term acceptability and tolerance of a new oral formulation of magnesium (TX 1341) and a reference magnesium]. - PubMed - NCBI
Intravenous and oral magnesium supplementations in the prophylaxis of cisplatin-induced hypomagnesemia. Results of a controlled trial. - PubMed - NCBI


Reproductive
Effectiveness of magnesium pidolate in the prophylactic treatment of primary dysmenorrhea. - PubMed - NCBI


Allergies
Magnesium pidolate in the treatment of seasonal allergic rhinitis. Preliminary data. - PubMed - NCBI

Georgi is saying that Magnesium salts are 10-15% bioavailable, but that I was able to find for Magnesium citrate for example, which is one the least Mg that is bioavailable.

Magnesium Glycinate is known to be well absorbed, but I couldn't find any exact bioavailability %, does anyone know?

I'm trying to understand if I normally take 800mg of Mg Glycinate, what would equal to Magnoli, as it seems to be pricy, only 30 serving for 333mg daily, unless taking this amount of Magnoli = taking almost double of my dose of Glycinate

 

[Sherbert]

Here you go:

“Magnesium glycinate is highly bioavailable, meaning it's easily absorbed by the body. The absorption of magnesium glycinate is about 23%”

https://www.google.com/search?q=wot+is+the+percent+biavailability+of+magnesium+glycinate&ie=UTF-8&oe=UTF-8&hl=en-us&client=safari

 

[G1986]

Here you go:

“Magnesium glycinate is highly bioavailable, meaning it's easily absorbed by the body. The absorption of magnesium glycinate is about 23%”

https://www.google.com/search?q=wot+is+the+percent+biavailability+of+magnesium+glycinate&ie=UTF-8&oe=UTF-8&hl=en-us&client=safari

wow, I can't believe I couldn't find it, thank you so much. it makes sense then about the Magnoil, I'm going to give this a try.

the study refer to people who have ileal resection though, these people may suffer from malabsorption

 

[G1986]

Low calcium can cause muscle twitching. See some other posts earlier in the thread related to magnesium : calcium balance.

how do you balance Ca Mg ratio with this product? every 1000mg of Ca = to how much of Magnoil? guessing 200 is enough?

 

[Sherbert]

Looking at his posts re calcium in this thread going back in time, it looks like one could start off with just magnesium by itself, or with magnesium and about half as much calcium. And then over time add or subtract each depending on symptoms…