Long-Term L-Serine Administration Reduces Food Intake And Improves Oxidative Stress And Sirt1/NFκB S

[Grapelander]

Serine has recently been shown to reduce oxidative stress and inflammation, which, when occurring in the hypothalamus, contribute to age-related obesity.
The results showed that the administration of 0.5% (w/v) L-serine significantly reduced food intake and body weight gain during the experiment. Moreover, the administration of 0.5% L-serine decreased the concentrations of leptin, malondialdehyde, interleukin-1β, and interleukin-6, while it increased those of superoxide dismutase and glutathione, in both the serum and hypothalamus.

 

[Goobz]

Thanks for posting this. I take l-serine and it seems to have had good results for me with cognition, mood and sleep. I remember seeing this study a while ago, it's good to be reminded.

There is a guy out there with a theory about Alzheimer's, Parkinsons, and ALS being caused by a neurotoxin from blue green algae, which displaces l-serine. Taking l-serine as a supplement is his recommended protection against it. From memory, he even had a pilot study showing it dramatically slowed down ALS progression, which barely anything seems to be able to do. Anyone who is interested can google "Paul Cox" and "Alzheimer's" or "ALS" etc.

 

[Elie]

Serine has recently been shown to reduce oxidative stress and inflammation, which, when occurring in the hypothalamus, contribute to age-related obesity.
The results showed that the administration of 0.5% (w/v) L-serine significantly reduced food intake and body weight gain during the experiment. Moreover, the administration of 0.5% L-serine decreased the concentrations of leptin, malondialdehyde, interleukin-1β, and interleukin-6, while it increased those of superoxide dismutase and glutathione, in both the serum and hypothalamus.

0.5% (w/v) is a measure of concentration, say 500 mg per 100 ml. But any idea what a daily dose would be.

 

[Blossom]

@Elie, I realize this is an old post but figured I’d put it here for any future interest.

Frontiers | L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury

Central nervous system (CNS) lesions are major causes of human death and disability worldwide, and they cause different extents of motor and sensory dysfunct...

www.frontiersin.org

 

[Validus]

Thoughts on phosphatidylserine being more optimal than just l-serine?

 

[Blossom]

@Ionson, I’ve only tried L-Serine so don’t really know. Hopefully someone with knowledge/experience of both will reply. I just recently tried L-Serine based on a recommendation for sleep. Since sleep has been my Achilles Heel after working nights off and on for 20 years I’m game to try just about anything tbh. What surprised me the most was how much better I handle stress. I wasn’t expecting it but my stress management score from Fitbit improved by an average of 8-10 points within a couple days of starting it for sleep.

 

[David PS]

Thoughts on phosphatidylserine being more optimal than just l-serine?

I like the idea of providing the body with the components that it needs to assemble phosphatidylserine itself. Phosphatidylserine is not always without risk the appears to be true if someone is taking certain pharmaceuticals.

Benefits of Phosphatidylserine Supplements

Learn more about the benefits and side effects of phosphatidylserine.

my.clevelandclinic.org

Foods With Most Serine and Threonine​

 

[Elie]

Thank you @Blossom
How much did you take and for hoe long?

 

[Blossom]

Thank you @Blossom
How much did you take and for hoe long?

I just started it last week and I’ve been taking 3g before bedtime so far.

 

[Elie]

I just started it last week and I’ve been taking 3g before bedtime so far.

Great. Thank you.

 

[AinmAnseo]

@Ionson, I’ve only tried L-Serine so don’t really know. Hopefully someone with knowledge/experience of both will reply. I just recently tried L-Serine based on a recommendation for sleep. Since sleep has been my Achilles Heel after working nights off and on for 20 years I’m game to try just about anything tbh. What surprised me the most was how much better I handle stress. I wasn’t expecting it but my stress management score from Fitbit improved by an average of 8-10 points within a couple days of starting it for sleep. View attachment 55892View attachment 55893

@Blossom
Are you still finding that serine is helping you with stress and sleep?

 

[Validus]

@Blossom
Are you still finding that serine is helping you with stress and sleep?

I am not taking it anymore, but it did help subtly for stress & sleep. Phosphatidylserine was superior initially, but the effects dropped off and subsided quickly.

These days, I've been using high dose melatonin after following Doris Loh's research on melatonin. I take about 3-5 grams around sleep (yes, grams, not milligrams). Usually 3 grams before I go to sleep and then another 2 grams before I wake up. That helps me sleep. I'm not 100% sure if I can recommend this approach if you're using it purely for sleep because of the grogginess the next day, but I'm not purely using it for sleep. If you look at her facebook page, you'll see more information on the benefits of higher dose melatonin.

 

[Ben.]

I am not taking it anymore, but it did help subtly for stress & sleep. Phosphatidylserine was superior initially, but the effects dropped off and subsided quickly.

These days, I've been using high dose melatonin after following Doris Loh's research on melatonin. I take about 3-5 grams around sleep (yes, grams, not milligrams). Usually 3 grams before I go to sleep and then another 2 grams before I wake up. That helps me sleep. I'm not 100% sure if I can recommend this approach if you're using it purely for sleep because of the grogginess the next day, but I'm not purely using it for sleep. If you look at her facebook page, you'll see more information on the benefits of higher dose melatonin.

How do you manage such high dosages? I remember 2 years ago i read about melatonin from some anti-aging guy and tried it with what i think was 3-4 teaspoons of melatonin and that knocked me out hard, slept 15 hours and woke up feeling sedated, nauseated and my brain felt like mush for over a day.