Finally Cured From Post Finasteride Syndrome

[VladSokolov]

If you're estrogenic maybe add DIM or low dose AI? Adding a DHT could help too.

And on that note new post from Kikel confirming what I already thought. But for some even DHT/DHB won't be enough and a HDACI will be necessary imo.

Alex Kikel on Instagram: "Although people can recover naturally, it is the minority (but obviously depends on the extent of your dysfunction.) #theprepcoach"

137 likes, 17 comments - alex_kikel on May 24, 2024: "Although people can recover naturally, it is the minority (but obviously depends on the extent of your dysfunction.) #theprepcoach".

www.instagram.com

I'm also in contact with a guy from reddit that's bascially 99% recovered thanks to TRT, HCG and taking a bunch of DHT steroids together like primo, proviron, etc. And he also took and still takes sulforaphane at 300mg/day (hdaci as strong as vorinostat according to a study). He also tried lithium and sodium butyrate but got bad effects from those.

What type of lithium did he use? These two people recovered using lithium carbonate.

CURED - PSSD Forum

"The last time people heard from me - in this thread - I was experimenting with Addyi and getting treatment for my PTSD. It turns out that Addyi did not do anything for me, and I discontinued after three months. Sometime in May, my psychiatrist prescribed lithium for my depression because I told him I was tired of SSRIs and their horrible side effects. I worked up to 450mg of lithium and have remained there. Combined with intensive psychotherapy and twelve weeks of pelvic floor therapy, I can now say that I am completely cured. I experience sexual desire, fantasies, lubrication, it's all back. It's like being back to my pre-SSRI self. These effects have remained since June or so. (For my OCD, I am actually low-dosing paroxetine, but this hasn't had an effect on my sex drive at all.)

After ten years, the nightmare is finally over. I want to kick myself because the solution was there in plain sight the whole time. "


View: https://old.reddit.com/r/PEDs/comments/trs2cx/advice_trt_trentrest/i3lay0r/


"I recovered with lithium carbonate 600 mg, 100 mg cyp weekly, and 30 mg tren eod. But if I could do it over I would do trest instead of tren although I love what tren does to my body from a bodybuilding perspective"

 

[Mister]

What type of lithium did he use? These two people recovered using lithium carbonate.

CURED - PSSD Forum

"The last time people heard from me - in this thread - I was experimenting with Addyi and getting treatment for my PTSD. It turns out that Addyi did not do anything for me, and I discontinued after three months. Sometime in May, my psychiatrist prescribed lithium for my depression because I told him I was tired of SSRIs and their horrible side effects. I worked up to 450mg of lithium and have remained there. Combined with intensive psychotherapy and twelve weeks of pelvic floor therapy, I can now say that I am completely cured. I experience sexual desire, fantasies, lubrication, it's all back. It's like being back to my pre-SSRI self. These effects have remained since June or so. (For my OCD, I am actually low-dosing paroxetine, but this hasn't had an effect on my sex drive at all.)

After ten years, the nightmare is finally over. I want to kick myself because the solution was there in plain sight the whole time. "


View: https://old.reddit.com/r/PEDs/comments/trs2cx/advice_trt_trentrest/i3lay0r/


"I recovered with lithium carbonate 600 mg, 100 mg cyp weekly, and 30 mg tren eod. But if I could do it over I would do trest instead of tren although I love what tren does to my body from a bodybuilding perspective"

Oh really interesting, haven't seen that second recovery.

And I'm not sure what type of lithium he used but I assume it was orotate, will ask him.

Have you seen this recent anecdote?

This guy also using carbonate and reporting massive improvements, even libido.


View: https://www.reddit.com/r/AccutaneRecovery/comments/1d1jiqa/ongoing_lithium_carbonate_300_mg_trial_pas/


Also read this thread it's about the difference between orotate and carbonate:


View: https://www.reddit.com/r/AccutaneRecovery/comments/1d4k1d1/pas_lithium_trials_important_info_about_dosing/


Theory why carbonate works better is because it contains much more elemental lithium than orotate, hence it also only being available under a prescription.

He also recommends adding B12 and follic acid, could improve effectiveness.

Btw also be aware of the side effects of high dose lithium, educate yourselves before starting. (as you should with everything)


I'm also reading more about hdaci's; Histone deacetylase - Wikipedia

 

[Mister]

New PAS recovery with DHB from Kikel:

Also interesting to note he tried things like HCG, TRT and proviron but that didn't help...

Alex Kikel on Instagram: "CLIENT CASE STUDY: PAS FULL REVERSAL AFTER 1 DOSE OF DHB This has been a case study that I have been waiting for post for a good 5-6 months now because I DO NOT want it to be taken out of context, and I also simply needed to

174 likes, 27 comments - alex_kikel on June 7, 2024: "CLIENT CASE STUDY: PAS FULL REVERSAL AFTER 1 DOSE OF DHB This has been a case study that I have been waiting for post for a good 5-6 months now because I DO NOT want it to be taken out of context, and I also simply needed to understand the...

www.instagram.com

Some interesting studies about various hdaci's:

Trichostatin A enhances 5 alpha reductase in neuronal tissue.

Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors - PubMed

The adrenergic and serotonergic stimulations of rat C6 glioma cells have previously been shown to induce the activation of steroid 5alpha-reductase (5alpha-R) gene expression, resulting in their differentiation through the production of neuroactive 5alpha-reduced steroid metabolites. In...

pubmed.ncbi.nlm.nih.gov

...HDAC inhibitor-treated patients may re-gain their androgen responsiveness...


"Since VPA pretreatment greatly enhances DHT-upregulated PSA level, the data indicate that VPA can increase androgen responsiveness of AR-positive PCa cells"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504398/

Valproic acid activity in androgen-sensitive and -insensitive human prostate cancer cells - PubMed

Histone deacetylase (HDAC) inhibitors are currently undergoing clinical trials in cancer patients on the basis of their effect on proliferation, differentiation and apoptosis demonstrated in vitro. The goal of this study was to assess the effects of an HDAC inhibitor, valproic acid (VA), on...

pubmed.ncbi.nlm.nih.gov

 

[FinVictim]

New PAS recovery with DHB from Kikel:

Also interesting to note he tried things like HCG, TRT and proviron but that didn't help...

Alex Kikel on Instagram: "CLIENT CASE STUDY: PAS FULL REVERSAL AFTER 1 DOSE OF DHB This has been a case study that I have been waiting for post for a good 5-6 months now because I DO NOT want it to be taken out of context, and I also simply needed to

174 likes, 27 comments - alex_kikel on June 7, 2024: "CLIENT CASE STUDY: PAS FULL REVERSAL AFTER 1 DOSE OF DHB This has been a case study that I have been waiting for post for a good 5-6 months now because I DO NOT want it to be taken out of context, and I also simply needed to understand the...

www.instagram.com

Some interesting studies about various hdaci's:

Trichostatin A enhances 5 alpha reductase in neuronal tissue.

Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors - PubMed

The adrenergic and serotonergic stimulations of rat C6 glioma cells have previously been shown to induce the activation of steroid 5alpha-reductase (5alpha-R) gene expression, resulting in their differentiation through the production of neuroactive 5alpha-reduced steroid metabolites. In...

pubmed.ncbi.nlm.nih.gov

...HDAC inhibitor-treated patients may re-gain their androgen responsiveness...


"Since VPA pretreatment greatly enhances DHT-upregulated PSA level, the data indicate that VPA can increase androgen responsiveness of AR-positive PCa cells"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504398/

Valproic acid activity in androgen-sensitive and -insensitive human prostate cancer cells - PubMed

Histone deacetylase (HDAC) inhibitors are currently undergoing clinical trials in cancer patients on the basis of their effect on proliferation, differentiation and apoptosis demonstrated in vitro. The goal of this study was to assess the effects of an HDAC inhibitor, valproic acid (VA), on...

pubmed.ncbi.nlm.nih.gov

Awesome finds Mister.

I'll definitely be adding in sulforaphane in my next TRT + trest + hCG cycle.

 

[Mister]

Great documentary about PFS and the dangers of pro fina zealots denying its existence.



Besides Haircafe's arguments and pseudo scientific analysis being dismantled in this great video, the pro fina zealot is also a known liar and he clearly has issues. There's a lot of troubling stuff you can find about this person online but the biggest irony is he actually admitted finasteride is not safe in the past and that he experienced side effects.

Can I Pull Off the Bald Look?

Thing is I’m sensitive to hair loss, it runs in my family and I have been struggling the past few years to contain it. Thing is though I’m also planning on starting my first cycle soon and realize there is a good chance I will lose it all even with hair loss treatment. What I use currently to...

forums.t-nation.com

Wonder how many men got FPS because of idiots like this...

 

[Mister]

Found 2 more recoveries;

Reddit - Dive into anything

www.reddit.com

He got better with enclomiphen 5mg/day + cialis.

Reddit - Dive into anything

www.reddit.com

This guy tried a lot of things but ultimately got better with a combo of TRT, primo, masteron, proviron, hcg, pea, andractim, sorghum and livagen. He also tried DHB and even Mtren.

So TRT, HCG + a ton of DHT derivatives seem imperative for his recovery.


And new PFS study:

(171) EFFECT OF FINASTERIDE TREATMENT AND ITS WITHDRAWAL IN THE RAT CORPUS CAVERNOSUM

AbstractObjectives. Finasteride is an inhibitor of the 5α-reductase used for treating androgenetic alopecia (AGA). However, despite its efficacy, it may ca

academic.oup.com

Abstract​

Objectives

Finasteride is an inhibitor of the 5α-reductase used for treating androgenetic alopecia (AGA). However, despite its efficacy, it may cause sexual alterations like erectile dysfunction (ED) that can persist after drug discontinuation, with the occurrence of post-finasteride syndrome (PFS). We previously described ED and altered pudendal nerve transmission in PFS patients treated for AGA, but the molecular mechanisms have not yet been explored. Therefore, we analyzed the effect of finasteride treatment and its withdrawal in an animal model.

Methods

Adult male rats were treated with finasteride (1 mg/day/rat) or vehicle (sesame oil) for 20 days and sacrificed 24h or 30 days after the last injection. The levels of androgens and catecholamines were assessed by mass spectrometry in the corpus cavernosum (CC) and plasma, respectively. In addition, targeted metabolomics coupled with a nitrate/nitrite colorimetric assay, and western blotting was performed in CC.

Results

Molecular alteration suggestive of ED were reported after treatment. Indeed, we observed the following: 1) a significant increase in the plasma levels of norepinephrine, and a decrease in those of epinephrine; 2) decreased protein levels of 5α-reductase type II in the CC, in line with increased testosterone and decreased dihydrotestosterone levels; 3) a reduction in the activity of nitric oxide synthase (NOS) and ornithine transcarbamylase (OTC); 4) a correlation between testosterone levels and NOS activity, and between dihydrotestosterone levels and OCT activity. No alterations in these parameters were observed at withdrawal.

Conclusions

These observations suggest that finasteride treatment, but not its withdrawal, induces molecular alterations in male rats that may be linked to erectile dysfunction. Considering that the nervous system is affected in PFS patients and animal models, and that male sexual behavior is under the control of complex neural circuits, future experiments will be dedicated to exploring whether finasteride withdrawal affects these circuits.

 

[Mister]

2 more people having strong improvements with lithium:


View: https://www.reddit.com/r/AccutaneRecovery/comments/1dn256d/comment/la5ghoq/


"During & Post Accutane (3 months - 20,20,40):

• Libido: 0-1/10 (watery and almost no semen)
• Emotions: 1-2/10 (no emotions)
• Overall energy: 2/10

2 months off Accutane:

• Libido: 1/10
• Emotions: 4/10
• Overall energy: 4-5/10

1 month on Lithium Carbonate (300mg) + B Complex & Inositol, gluten free diet (gluten was the real cause of my cystic acne), daily workouts and a healthy lifestyle:

• Libido: 8/10 (semen quality improved a LOT and I can get aroused, but no morning wood yet :/)
• Emotions: 9-10/10
• Overall energy: 7/10"

View: https://www.reddit.com/r/AccutaneRecovery/comments/1dnsl6a/lithium_works/


"Not so long ago, I came across this thread, and decided to try 450mg lithium carbonate. I have improved libido, orgasm, sensitivity."

And someone having massive improvements from DBOL and MENT (trestolone)

Strong androgens experience

Interesting. But I had the same effects from estrodiol Enanthate and right now on patches which is a completely different form. Actually I made a typo there. The first time I took estrodiol it was Enanthate form and I eventually switched to valerate because I wanted to have better short term...

forum.propeciahelp.com

"MENT + DBOL IS INCREDIBLE !!!

I FEEL AMAZING, I AM A NEW PERSON AND I HAVE FEELINGS AGAIN.

I have been on 10mg MENT a day + 20 Dbol a day split in two doses. My muscles are fuller than ever without even working out, I ejaculate 5 times a day, I am social, my joint pains are gone, I don’t have irrational fears or nightmares anymore, I can work for 15 hours a day without being tired, I have appetite again, my bloating and gas have dissapeared.

I WISH I HAD STARTED THIS PROTOCOLE 7 YEARS AGO !!"

And new PFS study:

https://journals.physiology.org/doi/abs/10.1152/physiol.2024.39.S1.1269

Epigenetic Effects of Finasteride on Dopaminergic Signaling Pathways: A potential contributor to Post-Finasteride Syndrome​

Abstract​

Dopamine, a widely-distributed neurotransmitter in the brain and elsewhere, is important for regulating reward-motivated behavior, sexual impetus, concentration, pleasure, emotions, and genital arousal. Findings have previously implicated aberrant dopaminergic neurotransmission in mental disorders, as well as sexual and erectile dysfunction. To evaluate the epigenetic effects of finasteride on dopaminergic signaling pathways, we treated human Leydig cells with finasteride and identified several dopaminergic pathways that were altered by differential methylation of component genes. These genes included those involved in the regulation of dopamine secretion and transport (OR56A4, OR13F1 and SYT4), the Phospholipase C-activating dopamine receptor signaling pathway (OR56A4 and OR13F1), the dopaminergic synapse (CALML4, COMT, GNAI2, GNAS, GNG10, GRIA1, GSK3A, GSK3B, KCNJ9, PPP2R2C, PPP2R3B, PPP2R3C, PPP2R5A, PPP2R5E) and the dopamine receptor activity and binding pathway (OR56A4, OR13F1). This alteration of gene methylation suggests a potential role of altered epigenetic regulation of dopaminergic pathways in the etiology and pathophysiology of post-finasteride syndrome (PFS), which should be further investigated.

 

[Mister]

One more PAS guy recovered for 90% with lithium, Nac, clomid and HGH


View: https://www.reddit.com/r/AccutaneRecovery/comments/1dq4s3q/comment/latcvgm/


And another PAS recovery with 6+ months of 200 mg TRT. I also was in contact with him and he said he only started to notice improvements from month 6.

Reddit - Dive into anything

www.reddit.com

PFS recovery from Moral Medicine.

He answered in comments what he did: "It took me around 3 years from the time I stopped finasteride. I did a heavy carnivior diet, took lithium, lifted weights when I could, and got plenty of sleep."

He also said in the video he's still taking a low dose of lithium.

 

[cheating_fate]

I want to thank @Mister for continuing to add to this thread

I've had pfs and/or pssd for a few years now (took both at the same time)

Have made some progress dialing in gut health, and ran hcg for 6 months with proviron thrown in for the final 3 before just running a full 20 week testosterone cycle with masteron and full pct

So...

3 months just hcg
3 months hcg and proviron
10 weeks test 500mg with hcg
10 weeks test 500mg mast 500mg with hcg
5 week pct with enclomiphene
Aromasin thrown in here and there

Did bloodwork and wasn't to my pre cycle levels so just did another 5 weeks of enclo

Currently doing 10 days of testagen peptide and then bloodwork again

I had several windows throughout the cycle,and feel better than pfs/pssd baseline now but nowhere near where I need to be

I plan to run Livagen after the testagen, as I already know it's not going to do the trick.

My question:

I've seen a supposed recovery via Kikel that was licorice root and livagen (so anti androgen + epigenetic change), I recall a recovery from berberine and livagen (anti androgen+ epi change) and we have a slew of supposed recoveries from heavy dht derivatives + hdac/epigenetic change...

So how would I distinguish which route to go, between anti androgen and androgen?

I would ideally like to use transscrotal dht cream plus livagen (because I feel straight dht to the testes is as close as one can get to complete opposite of finasteride) but can only source DHT raws from china, so would have to get it tested (which is no problem but more time, money,and then what if it has adulterants)

I still have plenty of proviron and mast on hand but would like to avoid the mast without a test base and would like to avoid jumping back on cycle and having to pct again.

Basically I just want to run dht or a derivative with the livagen for 20 days.

With this information, any recommendations?

 

[Mister]

Another one reporting improvements in the PFS group:

He also said adding Lithium was a game changer for him. And he had almost every bad PFS symptom in the book.


Also someone else in the group mentioned he fixed his libido with DHEA 100mg/day, still has other issues that are unresolved.


New video about PSSD and PFS, going through the recent studies and suggesting some treatment protocols.



@cheating_fate I'm happy to share what I find, hope others here will do too, especially recoveries so we get a better picture what could work.

Yeah definitely avoid the anti androgen treatments but still berberine is an interesting one with HDACI properties and one study suggests it's good for androgen receptor expression, posted it a few pages back, one guy recovered with it. Still there are other and safer routes to try first imo.

"We report that berberine decreased the transcriptional activity of AR. Berberine did not affect AR mRNA expression, but induced AR protein degradation. Several ligand-binding domain truncated AR splice variants have been identified and these variants are believed to promote the development of CRPC in patients. Interestingly, we found that these variants were more susceptible to berberine-induced degradation than the full-length AR. Furthermore, the growth of LNCaP xenografts in nude mice was inhibited by berberine and AR expression was reduced in the tumors, whereas the morphology and AR expression in normal prostates were not affected."

The most promising treatment is a HDACI + DHT derivative imo.

So yeah your plan could work, Livagen also opens the chromatic/epigenetic door. Although not many studies are available, so I have no idea how much or how strong it is compared to a HDACI like VPA or even Lithium. You'll need to do your own due dilligence on that, I know Kikel has talked about Livagen a lot, check his posts about it.

The transcrotal dht cream sounds like a good idea too but definitely get it third party checked if it's coming from china. And you only want to try it for 20 days? I really doubt that's long enough, for example Russo and Jasper did like 3-4 months of VPA/DHB combo. And be aware that even after 20 days of using a DHT derivative it can also theoretically shut you down and you needing to PCT, but for many a PCT isn't even necessary to get everything running again. And of course please do advise a doctor when you're starting a treatment.

 

[cheating_fate]

Another one reporting improvements in the PFS group:

He also said adding Lithium was a game changer for him. And he had almost every bad PFS symptom in the book.


Also someone else in the group mentioned he fixed his libido with DHEA 100mg/day, still has other issues that are unresolved.


New video about PSSD and PFS, going through the recent studies and suggesting some treatment protocols.



@cheating_fate I'm happy to share what I find, hope others here will do too, especially recoveries so we get a better picture what could work.

Yeah definitely avoid the anti androgen treatments but still berberine is an interesting one with HDACI properties and one study suggests it's good for androgen receptor expression, posted it a few pages back, one guy recovered with it. Still there are other and safer routes to try first imo.

"We report that berberine decreased the transcriptional activity of AR. Berberine did not affect AR mRNA expression, but induced AR protein degradation. Several ligand-binding domain truncated AR splice variants have been identified and these variants are believed to promote the development of CRPC in patients. Interestingly, we found that these variants were more susceptible to berberine-induced degradation than the full-length AR. Furthermore, the growth of LNCaP xenografts in nude mice was inhibited by berberine and AR expression was reduced in the tumors, whereas the morphology and AR expression in normal prostates were not affected."

The most promising treatment is a HDACI + DHT derivative imo.

So yeah your plan could work, Livagen also opens the chromatic/epigenetic door. Although not many studies are available, so I have no idea how much or how strong it is compared to a HDACI like VPA or even Lithium. You'll need to do your own due dilligence on that, I know Kikel has talked about Livagen a lot, check his posts about it.

The transcrotal dht cream sounds like a good idea too but definitely get it third party checked if it's coming from china. And you only want to try it for 20 days? I really doubt that's long enough, for example Russo and Jasper did like 3-4 months of VPA/DHB combo. And be aware that even after 20 days of using a DHT derivative it can also theoretically shut you down and you needing to PCT, but for many a PCT isn't even necessary to get everything running again. And of course please do advise a doctor when you're starting a treatment.

I think I've landed on proviron with the livagen as I have more than enough of it already, and it's relatively the safest and least suppressive. And, probably not a bad idea to throw in some hcg

 

[VladSokolov]

Dr. Healy advocates for lithium and I know of at least one PFS recovery and one PSSD recovery using Lithium. Dr. Healy posted the blog below. His research team has found down regulated p63 protein levels which is a regulator of many processes including stem cells. Lithium increases p63. I'm curious to try lithium + hcg personally.

Visual Snow, Visual Blur, Visual Weird - RxISK

Last week's post on Antidepressants and Retinal Detachment has generated a lot of very interesting comments. There will be another post on vision issues after this one - probably called Vision Weird. Serotonin reuptake inhibiting antidepressants can cause a range of problems on starting that...

rxisk.org

 

[Mister]

Dr. Healy advocates for lithium and I know of at least one PFS recovery and one PSSD recovery using Lithium. Dr. Healy posted the blog below. His research team has found down regulated p63 protein levels which is a regulator of many processes including stem cells. Lithium increases p63. I'm curious to try lithium + hcg personally.

Visual Snow, Visual Blur, Visual Weird - RxISK

Last week's post on Antidepressants and Retinal Detachment has generated a lot of very interesting comments. There will be another post on vision issues after this one - probably called Vision Weird. Serotonin reuptake inhibiting antidepressants can cause a range of problems on starting that...

rxisk.org

Interesting, btw if you have links to those recoveries pls post them.


Also found this PFS hcg recovery, interestingly he got PFS when he was on TRT, seems adding HCG was enough for him to fix his libido and depression.


View: https://www.reddit.com/r/FinasterideSyndrome/comments/1duqhmq/i_think_hcg_cured_me/


And new video from Kikel talking about HDACI's:

 

[VladSokolov]

Interesting, btw if you have links to those recoveries pls post them.


Also found this PFS hcg recovery, interestingly he got PFS when he was on TRT, seems adding HCG was enough for him to fix his libido and depression.


View: https://www.reddit.com/r/FinasterideSyndrome/comments/1duqhmq/i_think_hcg_cured_me/


And new video from Kikel talking about HDACI's:

They're at the top of this page.

I think lithium and hcg is a good combo to try. Dr. Healy thinks lithium is a potential treatment because it increases p63 and ACE2. I wonder though if the benefits people see are due to lithium's effect on GABA receptors.

 

[Mister]

New PFS recovery from Kikel, guy had PFS for 10 years.

Alex Kikel on Instagram: "CLIENT CASE STUDY: PFS Reversal - Charlie’s Story I am trying really hard to space out these client case studies because I do not want to keep repeating the same products or protocols as every reversal is unique and I’m tryi

59 likes, 6 comments - alex_kikel on August 6, 2024: "CLIENT CASE STUDY: PFS Reversal - Charlie’s Story I am trying really hard to space out these client case studies because I do not want to keep repeating the same products or protocols as every reversal is unique and I’m trying to highlight...

www.instagram.com

Did topical androsterone on genitals for his libido and also cyproheptadine an antihistamine for libido that helped his serotonine levels and "5HT1A" reset.

Also talking about OTC supplements, but not specified what.

Interesting study about cyproheptadine:

Cyproheptadine treatment of sexual dysfunction induced by serotonin reuptake inhibitors - PubMed

Treatment of serotonin reuptake inhibitors (SRIs) is associated with sexual dysfunction. The cause of this dysfunction is unclear but may be related to stimulation of the serotonergic system. In the present article, we describe seven patients in whom iatrogenic sexual dysfunction induced by SRIs...

pubmed.ncbi.nlm.nih.gov

"Our preliminary observation suggests that some patients with sexual dysfunction associated with SRI treatment, mainly decreased libido and anorgasmia, may benefit from cyproheptadine administration. The role of 5HT-2 antagonists in SRI-induced sexual dysfunction merits further investigation."

About 5HT1A;

5HT1A involvement in sexual function

5-HT1A subtype is involved in controlling both behavioral and hormonal indices of sexual arousal in male mice, while the 5-HT1B receptors antagonise sexual motivation, but do not modify the hypothalamic-pituitary-testicular response.


"Brain serotonin (5-HT) neurotransmission plays an important role in male sexual behavior and it is well established that activating 5-HT1A receptors in rats facilitate ejaculatory behavior."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136541/

 

[Mister]

New post from Kikel saying he recovered another 2 people with PFS but no details how.

Alex Kikel on Instagram: "I HAVE MASSIVE PLANS FOR THE PFS COMMUNITY!!!! I just finished up a round of check ins and had 2 BACK TO BACK RECOVERIES - and YES I teared up a LOT! One PFS one PSSD - the first guy had only been suffering for 3 months but

216 likes, 29 comments - alex_kikel on August 11, 2024: "I HAVE MASSIVE PLANS FOR THE PFS COMMUNITY!!!! I just finished up a round of check ins and had 2 BACK TO BACK RECOVERIES - and YES I teared up a LOT! One PFS one PSSD - the first guy had only been suffering for 3 months but the second guy...

www.instagram.com

PSSD recovery



A PFS guy claiming he has constant improvements with lithium carbonate 600mg and proviron 25-50mg


View: https://www.reddit.com/r/AccutaneRecovery/comments/1eq6hy7/some_person_told_me_that_lithium_cant_replace/


Someone who recoverd to 80%


View: https://x.com/AlphaGels/status/1823179289115930769


And a new PFS article on second life, sucks most of it is behind a paywall though

Post Finasteride Syndrome: The Complete Guide - SecondLife

1. An Introduction to Finasteride and DHT Where and How is DHT synthesised? The body synthesises only a tiny amount of DHT per day as compared to testosterone. An average male may produce as much as 6mg of testosterone, but approximately 0.3mg of DHT – representing approximately a 5% conversion...

secondlifeguide.com

 

[Mister]

PSSD recovery with Kisspeptin a neuropeptide, but also took mesterolone and test enanthate but that didn't work well.

His dosage:

"usually 0.5~1 mcg 3x per day for 5 days, take a day or two off then back again.

sometimes I'll take 5 mcg at once.

I started off with standard doses of 100-200 mcg and crashed quickly so slowly but surely tapered down to my desired doses."



View: https://www.reddit.com/r/PSSD/comments/1euo794/i_have_recovered_for_over_a_year_with/


Really interesting compound that most haven't tried yet as far as I know. Also studies showing it helps with libido, etc

"NeuroSearch AS said it sees the hormone-like peptide kisspeptin as a libido stimulator and a treatment of abnormal puberty or growth.

The Danish healthcare company said its scientists, working in collaboration with scientists at Centre Nationale de la Recherche Scientifique (CNRS) in Strasbourg, have shown that kisspeptin plays a central role in controlling libido.

The peptide fully re-established the sexual function of hamsters, which are sexually active only during the summer period, while they were kept under winter-like conditions, NeuroSearch said.

‘These are important findings which demonstrate that sexual behaviour is controlled by the brain and that cells containing kisspeptin fully or partly regulate libido,’ it said.

Kisspeptin, which was discovered in 2003, has so far been considered only to influence the development of puberty.

NeuroSearch said the latest research findings leave new opportunities for the treatment of low or no libido as well as for the treatment of abnormal puberty or growth."

Effects of Kisspeptin in Men With Hypoactive Sexual Desire Disorder

This randomized clinical trial investigates the physiological, behavioral, neural, and hormonal effects of kisspeptin administration in men with hypoactive sexual desire disorder.

jamanetwork.com

Also some positive anecdotes about Sorghum syrup on reddit and in the whatsapp group.


View: https://www.reddit.com/r/NootropicsDepot/comments/1bzz6u1/comment/kyviro1/

 

[VladSokolov]

One more PAS guy recovered for 90% with lithium, Nac, clomid and HGH


View: https://www.reddit.com/r/AccutaneRecovery/comments/1dq4s3q/comment/latcvgm/


And another PAS recovery with 6+ months of 200 mg TRT. I also was in contact with him and he said he only started to notice improvements from month 6.

Reddit - Dive into anything

www.reddit.com

PFS recovery from Moral Medicine.

He answered in comments what he did: "It took me around 3 years from the time I stopped finasteride. I did a heavy carnivior diet, took lithium, lifted weights when I could, and got plenty of sleep."

He also said in the video he's still taking a low dose of lithium.

Do you have more info on the guy that recovered with lithium and clomid?

I'm on lithium carbonate 450mg right now and I definitely see mental/emotional improvement, genital sensitivity improvement, some libido improvement. I'm also taking hcg 250mcg MWF but I'm considering switching to clomid since it's more effective as increasing testosterone.

 

[MCurtone]

Do you have more info on the guy that recovered with lithium and clomid?

I'm on lithium carbonate 450mg right now and I definitely see mental/emotional improvement, genital sensitivity improvement, some libido improvement. I'm also taking hcg 250mcg MWF but I'm considering switching to clomid since it's more effective as increasing testosterone.

I would suggest trying a higher dose of HCG, as long as you don't get estrogen issues. HCG is great for raising test and 250-300iu daily had me at 1200 ng/dl. But yes, it can skyrocket E. But it has more benefits than clomid in my opinion.

 

[VladSokolov]

Can someone provide some clarification here. It seems JoeKool used some large doses of hcg and also provision before doing his 250iu MWF regimen.