Haidut - Can you provide a little more info on the safety of this substance? Especially in the doses in lapodin, potentiated by the DMSO?
Here's "title-ified" versions of the links.
Miscellaneous
- Preclinical Pharmacokinetic Evaluation of β-Lapachone: Characteristics of Oral Bioavailability and First-Pass Metabolism in Rats.
- Cancer therapy with beta-lapachone.
- β-Lapachone attenuates mitochondrial dysfunction in MELAS cybrid cells.
- Beta-lapachone inhibits pathological retinal neovascularization in oxygen-induced retinopathy via regulation of HIF-1α.
- Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice.
- β-lapachone accelerates the recovery of burn-wound skin.
- Corpus cavernosal smooth muscle relaxation effect of a novel AMPK activator, beta-lapachone.
- Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB.
- In vitro and in vivo wound healing-promoting activities of beta-lapachone.
- Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by ...
Cancer/Hypoxia
- ARQ-761 Treatment With Gemcitabine/Nab-Paclitaxel Chemotherapy In Pancreatic Cancer
- ARQ 501 in Combination With Gemcitabine in Subjects With Pancreatic Cancer
- Inhibition of radiation-induced neoplastic transformation by beta-lapachone.
- β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1.
- Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.
- Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors To Treat an Aggressive Subtype of Diffuse Large B-Cell Lymphoma.
- Beta-Lapachone Suppresses Non-small Cell Lung Cancer Proliferation through the Regulation of Specificity Protein 1.
- Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation.
- Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells.
- Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma.
- UDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of β-lapachone in human colon cancer cells.
- NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-l...
- eIF2 kinases mediate β-lapachone toxicity in yeast and human cancer cells.
- Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy.
- Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent.
- β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway.
- β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells.
- The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1.
- Effects of β-lapachone, a new anticancer candidate, on cytochrome P450-mediated drug metabolism.
- Synergistic enhancement of antitumor effect of β-Lapachone by photodynamic induction of quinone oxidoreductase (NQO1).
- Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells.
- Administration of the optimized β-Lapachone-poloxamer-cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human...
- β-Lapachone analogs with enhanced antiproliferative activity.
- Growth inhibitory effects of 3'-nitro-3-phenylamino nor-beta-lapachone against HL-60: a redox-dependent mechanism.
- β-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells.
- Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.
- Beta-lapachone (LAPA) decreases cell viability and telomerase activity in leukemia cells: suppression of telomerase activity by LAPA.
- Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt.
- Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis.
- Comparative studies of the effects of Tabebuia avellanedae bark extract and beta-lapachone on the hematopoietic response of tumour-bearing mice.
- Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells.
- Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines.
- Selective induction of necrotic cell death in cancer cells by beta-lapachone through activation of DNA damage response pathway.
- Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation...
- beta-lapachone induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2 family and activation of caspases.
- Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.
- Down-regulation of cyclooxygenase-2 and telomerase activity by beta-lapachone in human prostate carcinoma cells.
- Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity.
- Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1.
- beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells.
- Suppression of human prostate cancer cell growth by beta-lapachone via down-regulation of pRB phosphorylation and induction of Cdk inhibitor p21(WA...
- Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer.
- beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells.
- Potent induction of apoptosis by beta-lapachone in human multiple myeloma cell lines and patient cells.
- beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3.
- beta-lapachone induces cell cycle arrest and apoptosis in human colon cancer cells.
- Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: combining drugs imposes different artificial checkpoints.
- Release of mitochondrial cytochrome C in both apoptosis and necrosis induced by beta-lapachone in human carcinoma cells.
- Induction of apoptosis in MCF-7:WS8 breast cancer cells by beta-lapachone.
- Involvement of hydrogen peroxide in topoisomerase inhibitor beta-lapachone-induced apoptosis and differentiation in human leukemia cells.
- beta-Lapachone induced cell death in human hepatoma (HepA2) cells.
- Induction of apoptosis by beta-lapachone in human prostate cancer cells.
- Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.
- beta-Lapachone: synthesis of derivatives and activities in tumor models.
- beta-Lapachone enhancement of lipid peroxidation and superoxide anion and hydrogen peroxide formation by sarcoma 180 ascites tumor cells.
Cortisol/Diabetes/Obesity
Inflammation/CVD
- Cytoprotective effect of β-lapachone by inducing heme oxygenase-1 expression and AMP-activated protein kinase activation in human endothelial cells.
- β-Lapachone ameliorates lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice.
- β-Lapachone, a substrate of NAD(P)H:quinone oxidoreductase, induces anti-inflammatory heme oxygenase-1 via AMP-activated protein kinase activation ...
- Synthesis and anti-inflammatory evaluations of β-lapachone derivatives.
- Effects of β-lapachone on the production of Th1 and Th2 cytokines in C57BL/6 mice.
- Anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone).
- Inhibition of inducible nitric oxide synthase by beta-lapachone in rat alveolar macrophages and aorta.
Neurological/Mental/Mood
- β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia.
- β-Lapachone ameliorization of experimental autoimmune encephalomyelitis.
- Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia.
Endotoxin/Gastrointestinal/Liver/Pancreas/Kidney
- β-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD⁺, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation.
- β-Lapachone alleviates alcoholic fatty liver disease in rats.
- beta-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality.
Anti-viral/Anti-bacterial/Anti-parasitic/Anti-fungal
- Assessment of β-lapachone loaded in lecithin-chitosan nanoparticles for the topical treatment of cutaneous leishmaniasis in L. major infected BALB/...
- ANTHELMINTIC ACTIVITY OF LAPACHOL, β-LAPACHONE AND ITS DERIVATIVES AGAINST Toxocara canis LARVAE.
- Synthesis and anti-Trypanosoma cruzi activity of new 3-phenylthio-nor-β-lapachone derivatives.
- Ultrastructural analysis of β-lapachone-induced surface membrane damage in male adult Schistosoma mansoni BH strain worms.
- β-Lapachone: a naphthoquinone with promising antischistosomal properties in mice.
- β-Lapachone activity in synergy with conventional antimicrobials against methicillin resistant Staphylococcus aureus strains.
- Identification of nor-β-lapachone derivatives as potential antibacterial compounds against Enterococcus faecalis clinical strain.
- Activity of β-lapachone derivatives against rifampicin-susceptible and -resistant strains of Mycobacterium tuberculosis.
- The evaluation of quinonoid compounds against Trypanosoma cruzi: synthesis of imidazolic anthraquinones, nor-beta-lapachone derivatives and beta-la...
- Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethaso...
- In vitro synergic effect of beta-lapachone and isoniazid on the growth of Mycobacterium fortuitum and Mycobacterium smegmatis.
- Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.
- Mitochondrial disruption and DNA fragmentation in Trypanosoma cruzi induced by naphthoimidazoles synthesized from beta-lapachone.
- Antiplasmodial activity of naphthoquinones related to lapachol and beta-lapachone.
- Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: identification of target organelles.
- Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from beta-lapachone.
- Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei...
- A trypanocidal phenazine derived from beta-lapachone.
- Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone.
- Evaluation of the toxicity of 3-allyl-beta-lapachone against Trypanosoma cruzi bloodstream forms.
- Effect of beta-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi.
- Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria.
- Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in beta-lapachone-treated Trypanosoma cruzi epimast...
- beta-Lapachone, an inhibitor of oncornavirus reverse transcriptase and eukaryotic DNA polymerase-alpha. Inhibitory effect, thiol dependence and spe...
- Effect of beta-lapachone on hydrogen peroxide production in Trypanosoma cruzi.
- Trypanosoma cruzi: ultrastructural and metabolic alterations of epimastigotes by beta-lapachone.
