hdac

A very interesting study and a "synchronicity" event as well, considering the recent in-vivo experiments I conducted with a combination of vitamin B1 and vitamin B3 (niacinamide) in a mouse xenograft model of human mantle-cell lymphoma. In that experiment of mine, HED of 15mg/kg B1 and 30mg/kg...

Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin, and NO pathways has significantly improved outcomes. However, for the vast majority of patients, PAH remains a...

The use of HDAC inhibitors such as valproic acid or various butyrate salts for cancer treatment has been studied experimentally for decades. Until now, it was assumed that the process of histone acetylation and deacetylation affected mostly the processes associated with cell division and...

I just posted a study showing that inhibition of SIRT1 is anti-estrogenic, and SIRT1 inhibitors like niacinamide have similar effects to the estrogen receptor antagonist fulvestrant. Niacinamide Is Anti-estrogenic | Ray Peat Forum This study shows that, again through inhibition of SIRT1...

Yet another strong point for niacinamide. I am beginning to wonder if there is any condition or biomarker of disease that niacinamide cannot affect. Peat has written many times about the sirtuin genes and their promoter resveratrol. While there is already quite a bit of evidence that SIRT1...

Ray wrote recently in one of his newsletters about Histone Deacetylase (HDAC) inhibitors and their role in protecting from cancer. Niacinamide is one well-known HDAC inhibitor. This study lists some other potential HDAC inhibitor some of which have been mentioned by Peat before but not in...