fatty acid oxidation

This is yet another study that calls into serious doubt the main dogma of diabetic pathology provided by allopathic medicine. Namely, mainstream medicine claims that the well-known kidney damage occurring in majority of advanced cases of diabetes II is caused by the elevated blood glucose in...

https://pubmed.ncbi.nlm.nih.gov/17585026 Abstract We conducted this study to quantify the oxidation of exogenous acetate and to determine the effect of increased acetate availability upon fat and carbohydrate utilization in humans at rest. Eight healthy volunteers (6 males and 2 females)...

Not sure if my readers have noticed it, but Big Pharma has drastically increased their bashing of aspirin since the pandemic started. Those attacks began when a few studies published back in 2020 demonstrated that aspirin users had a much lower risk of both contracting and dying from COVID-19...

My previous post highlighted the pathological mTOR-mediated aerobic glycolysis caused by endotoxin, so I thought it should be balanced with an example of glycolysis-boosting when oxidative phosphorylation is unimpaired. The experiment looked both in vitro and in vivo at the effects of kahweol, a...

Just a few weeks after my post on how excessive fatty acid oxidation (FAO) drives cancer, below is another great new study, which corroborates once again the hypothesis that excessive FAO (and/or fatty acid supply into the mitochondria of the cell) result in impaired OXPHOS and organ damage...

The study below is one perhaps the most comprehensive review published to date, challenging the medical dogma that cancer is a genetic/mutation disease. As the study aptly explains, the evidence, spanning as far back as Otto Warburg's original work on this disease, is overwhelmingly in support...

One of the few studies out there that not only links cancer with impaired OXPHOS, but demonstrates directly the role of reductive stress (exemplified by the NAD/NADH ratio) in cancer's appetite for fats as fuel required for the cancer survival and proliferation/metastasis. It also once again...

Hey everyone, Upon doing some research on fatty acid oxidation (FAO) inhibiting drugs (like meldonium), I thought to myself, do these kind of drugs prevent us from losing fat? How would the body burn fat, if the fatty acid oxidation is inhibited? Or perhaps the drugs do not fully inhibit it? Can...

Just a placeholder thread for now, until I organize all the references I think would be interesting/relevant to post here. For now, a quote from Peat on a recent interview about quinine and inflammation/ACE2, a very long thread/discussion in regards to quinine's anti-serotonin effects, and some...

https://raypeatforum.com/community/threads/cancer-cells-addicted-to-fat-and-use-fat-oxidation-for-survival.7639 https://raypeatforum.com/community/threads/forcing-the-heart-to-burn-glucose-instead-of-fat-may-cure-heart-failure.33094 Dr. Stephen Hussey To understand why cancer in the heart is...

Spinal muscular atrophy (SMA) is an autosomal recessive condition that results in pathological deficiency of the survival motor neuron (SMN) protein. SMA most frequently presents itself within the first few months of life and is characterized by progressive muscle weakness. As a neuromuscular...

Just a quick post in regards to a study that found the drug donepezil - commonly used to "treat" Alzheimer's Disease (AD) - may improve mitochondrial function in muscles. While the findings of the study in regards to donepezil are debatable and not particularly interesting, buried inside the...

I have been experiencing immense hair loss since May of this year. Both a receding hairline and intense shedding when I run my fingers through my hair. I have implemented everything under the sun from oysters, aspirin, oxtail, raw liver, methyl blue, cutting training, increasing protein, to...

A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without...

Altered the title to make it fit. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome Full text ABSTRACT Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic...

The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the...

Once again, the role of excessive fat oxidation is on full display. While mainstream medicine is slowly and reluctantly admitting that cancer may in fact be a metabolic disease, it still views glucose as the primary oncogenic factor in the diet. Yet, little by little, research demonstrates that...

The evidence for the role of excessive FAO in cancer keeps piling on. As many of my readers know, triple-negative breast cancer is one of the most difficult to treat and its proportion of total breast cancer cases has been steadily rising over the last 20 years. When a patient is diagnosed with...

Most of the forum readers are familiar with the "mysterious" condition pulmonary arterial hypertension (PAH). I put "mysterious" in quotes, because mainstream medicine claims that its cause is unknown, its onset is unpredictable, there is no cure, and females are affected 4-5 times more often...

One of the blockbuster studies I have seen over the last 12 months. It reads as if written by Peat himself and discusses tissue regeneration, Randle cycle, dietary control of metabolism, etc. AFAIK this is the first study brave enough to demonstrate that simply switching fuel types in an...