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anti-aging

  1. Philomath

    Why isn't this thread about Cocoa a bigger deal?

    "Energy and structure are interdependent at every level" -Ray Peat If the primary focus of this forum revolves around Dr. Peat's theories concerning the significance of energy production, why aren't threads like these receiving more attention...
  2. TruffleGnocchi

    DHEA levels in young children? And how to prevent it's conversion?

    There are papers talking about DHEA decline and supplementation could resolve a lot of problems related to aging. I see some sources say DHEA levels are low or significantly lower in childhood than in teens or young adults. Is this really the hormone of such importance if this is true? When I...
  3. HeartGold

    Sun damage

    Hi! Is it possible to heal this type of sun damage? Does it look dehydrated? I’m only 28 and had great skin until I was 26. My guess is that it’s from a combination of sun, stress and pollution. I tried niaciamide (orally), thiamine(orally), tallow and progesterone cream but not much helped...
  4. TruffleGnocchi

    Why is male HRT so easy, compared to female HRT?

    Hello everyone. I wanted to ask via a reply to this post: If Estrogen Is So Bad, Why Does It Immediately Help but cannot because of new account restriction, so I'm making this, I hope it's in the right topic. Why is it that a lot of older men just do Testosterone + AI or Testosterone only and...
  5. Mauritio

    Selegiline also effective for anti-aging in dogs

    Good news for the anti-aging crowd: Selegiline also works as an anti-aging drug in dogs. Now it has been shown to be effective in four different species (hamsters, rats, mice and dogs), which shows that it acts on a fundamental, evolutionary conserved mechanism, which makes it more likely that...
  6. Ras

    Anti-Aging Breakthrough: Detoxing Body of Harmful Fat By-Products To Extend Lifespan

    The study discussed here presents evidence that clearing the body of the fat byproducts glycerol and glyceraldehyde could lead to an increased lifespan. In light of those data, a supplement that comes to mind is dihydromyricetin, which causes the body to produce more alcohol dehydrogenase and...
  7. Tarmander

    Rapamycin is Fantastic and Worth Trying

    There really has not been much talk of Rapamycin on this forum. When it was brought up in the past, its mTOR inhibition was often talked about as a negative. Many assumed this would lead to muscle wasting and catabolism. Well I am here to tell you, it is worth looking into. Alone it has given...
  8. PeskyPeater

    Wheat bran- but not oat bran-enriched diets increase the mucosal height of the cecum and colon of newly weaned and aged rats

    "In spite of the reports mentioned above, it is not known whether the effect of a water-soluble fiber-enriched diet (the main source of SCFA) on the mucosa of the large bowel is more pronounced than that of an insoluble fiber-enriched diet. In the present study, we determined the effect of...
  9. Sefton10

    Vitamin D supplementation is associated with slower epigenetic aging

    Adverse effects of low vitamin D level on mortality and morbidity are controversially discussed. Especially older people are at risk for vitamin D deficiency and therefore exposed to its potentially harmful consequences. A way of measuring differences in the biological age is through DNA...
  10. A

    Hypercapnia-inducible factor: a hypothesis | Aging and longevity

    Abstract Cells and tissues sense and respond to hypercapnia by global activation or down-regulation of hundreds of genes and switching on/off a number of signaling and metabolic pathways. We hypothesize for the first time that such complex rearrangements are hardly possible without subtle...
  11. youngsinatra

    Rate My Anti-Aging Stack

    Hello everyone, I am personally very interested in longevity and extending healthy lifespan. I am curious if some of you are also into this field of interest and could give me some advice for what you would change/add/remove. My supplement stack: 1. Fat-solubles: (All dissolved in MCT-oil...
  12. P

    55 year-old looks like 25

    Interesting video about a 55 year-old photographer who looks like an elite 25 year-old fitness model. He's 55 Years Old But Looks 25... Reacting To Chuando Tan Reveal His Secrets Summary: He looks the same as he did in the late 1980s, in his 20s. He doesn't drink or smoke, doesn't drink coffee...
  13. haidut

    Policosanol Is Antiviral And A Potent Inducer Of Anti-aging Gene Klotho

    This post is a good complement to the recent ones I did on androgens, estrogens and their opposing effects on the expression of the anti-aging gene Klotho. While I was doing research on that gene, I had a "random" thought pop up in my mind. It is well-known that some Caribbean countries have a...
  14. haidut

    Androgens Boost, Estrogen Inhibits, Anti-aging Gene Klotho

    This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR)...
  15. haidut

    Topical DHEA Has Potent Anti-aging Effects On Human Skin

    I often get emails in regards to possible interventions with anti-aging effects on skin. The study I usually quote is an old one (circa 1967) that did extensive tests on 200+ people with age range of 57-88 years residing in a retirement home, and demonstrated that topical testosterone (1%) cream...
  16. haidut

    Simply Diluting "old Blood" Has The Same Anti-aging Effects As Parabiosis

    The topic of using blood from young people to stave off aging and disease is hardly new. Rumors have been circulating for centuries that the old and rich use all kinds of gruesome methods to acquire blood from young people and use that blood for all sorts of bizarre rejuvenating procedures...
  17. L

    Deprenyl – Peatarian-Safe?

    Has anyone asked Ray Peat his opinion about this drug? Would he think it is safe for long term usage? Do you think it is safe, and good to use as a nootropic?
  18. haidut

    6-keto P4 - Liquid 6-ketoprogesterone For Lab/R&D

    As many forum users know, preventing tissue destruction as a result of hypothyroidism and stress is one of the main topics the pro-metabolic approach focuses on. While tissue catabolism can be drive by a number of mediators working in tandem, the main catabolic steriod in the human organism is...
  19. H

    Best Anti-Wrinkle Supplements For Men?

    MSM, K2 MK-4, Progesterone, Vitamin A...Anything else?
  20. haidut

    Calcirol - Liquid Vitamin D3

    Just like the other vitamin products we have released, this product does not really need any introduction to anybody familiar with Peat's work. So, unlike other products of ours, there won't be as many references listed in support of this product but I think even the few ones below are enough to...
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